LitCovid-sentences  

PMC:7605643 / 7001-9284 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T49 0-7 Sentence denotes Methods
T50 9-48 Sentence denotes ACE2 interaction network and hypothesis
T51 49-111 Sentence denotes ACE2 is the proposed attachment site for SARS-CoV-2 in humans.
T52 112-265 Sentence denotes Protein interaction studies were conducted around this protein to understand how the attachment of virus with ACE2 affects the pathology in human system.
T53 266-425 Sentence denotes Computational protein-interaction analysis provides the knowledge about the indirect and probable interactions which might be occurring with the query protein.
T54 426-527 Sentence denotes This is a very useful approach for predicting the new interactions of proteins in the in-vivo system.
T55 528-611 Sentence denotes Cytoscape v3.7.2 (Shannon et al., 2003) was used to design the interaction network.
T56 612-733 Sentence denotes BiNGO plugin was used for the analysis and prediction of overrepresented pathways in master network (Maere et al., 2005).
T57 734-850 Sentence denotes Overrepresented pathways are the set of pathways which are collectively taken-up by the set of proteins under study.
T58 851-918 Sentence denotes This helps in understanding the final fate of protein-interactions.
T59 920-965 Sentence denotes Pharmaco-networking of N. sativa constituents
T60 966-1041 Sentence denotes Literature mining was done to find the different constituents of N. sativa.
T61 1042-1148 Sentence denotes Their PubChem IDs (Kim, et al.) were retrieved, and constituents (ligands) were downloaded in .SDF format.
T62 1149-1247 Sentence denotes QikProp v6.3 (rel 13) was used to perform computational ADME analysis (Schrödinger Release 2020-1:
T63 1248-1295 Sentence denotes QikProp, Schrödinger, LLC, New York, NY, 2020).
T64 1296-1363 Sentence denotes ADME stands for Absorption, Distribution, Metabolism and Excretion.
T65 1364-1426 Sentence denotes It was performed to predict the druggability of the compounds.
T66 1427-1568 Sentence denotes Further, receptors were predicted for constituents of N. sativa in human system by using Swiss target prediction tool (Gfeller et al., 2014).
T67 1569-1665 Sentence denotes These receptors were additionally used to analyse their mode of action via interaction analysis.
T68 1667-1682 Sentence denotes Docking studies
T69 1683-1778 Sentence denotes ACE2 was downloaded from PDB database in Maestro v12.3 environment (Schrödinger Release 2020-1:
T70 1779-1860 Sentence denotes Maestro, Schrödinger, LLC, New York, NY, 2020) and prepared for docking analysis.
T71 1861-1950 Sentence denotes All the ligands of N. sativa were processed by using LigPrep (Schrödinger Release 2020-1:
T72 1951-2041 Sentence denotes LigPrep, Schrödinger, LLC, New York, NY, 2020) to generate all the possible stereoisomers.
T73 2042-2125 Sentence denotes Extra-Precision (XP) docking was performed using Glide (Schrödinger Release 2020-1:
T74 2126-2171 Sentence denotes Glide, Schrödinger, LLC, New York, NY, 2020).
T75 2172-2283 Sentence denotes Docking analysis was performed to analyse the best binding ligand from N. sativa constituents to ACE2 receptor.