LitCovid-sentences  

PMC:7605643 / 35429-38643 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T200 0-103 Sentence denotes In the present study cytoscape was used to visualise and analyse the main interacting partners of ACE2.
T201 104-215 Sentence denotes A PPI master network was created around ACE2 and they key first line and second line receptors were identified.
T202 216-553 Sentence denotes In addition, BiNGO analysis of the hub nodes was performed to determine the Gene Ontology categories which are statistically overrepresented in a set of obtained proteins to decipher the major molecular processes affected when ACE2 binds to the human receptors and when all the genes obtained in our network map interact with each-other.
T203 554-649 Sentence denotes The top ten obtained hub nodes were ACE2, INS, AKT1, VEGFA, IL6, ALB, ACE, AGT, Renin and KNG1.
T204 650-760 Sentence denotes IL-6 is a pro-inflammatory cytokine and is suggested to be associated with SARS severity (Zhang et al., 2004).
T205 761-872 Sentence denotes IL-6 is being used as a potential biomarker whose measurements seem as a reliable measure to diagnose COVID-19.
T206 873-986 Sentence denotes IL6 is also involved in host defence against bacteria related inflammation diseases (Narazaki & Kishimoto, 2018).
T207 987-1111 Sentence denotes In diseases, the IL-6 inhibitory strategy begins with the development of the anti-IL-6 receptor antibody, tocilizumab (TCZ).
T208 1112-1199 Sentence denotes Clinical trials for Intravenous Tocilizumab for severe COVID-19 pneumonia are underway.
T209 1200-1348 Sentence denotes TCZ therapy is being given to prevent/treat the cytokine storms emerged as an outcome of severe COVID-9 infections due to sharp rise in IL-6 levels.
T210 1349-1449 Sentence denotes In moderately and critically ill patients, repeated TCZ therapy seems beneficial (Luo et al., 2020).
T211 1450-1630 Sentence denotes Cytokine-mediated signaling pathways, which also have a key role in SARS-CoV-1 infection, are the most dysregulated pathways in early SARS-CoV-2 infection (Catanzaro et al., 2020).
T212 1631-1770 Sentence denotes The change in cytokines’ expression (i.e. IL6, IL8, IL17, CCL2) are indicative of pro-inflammation in early stages of SARS-CoV-2 infection.
T213 1771-1863 Sentence denotes A moderate exposure to hypoxia combined with viral infection increases the lung VEGF levels.
T214 1864-1983 Sentence denotes This increase is mediated by an elevation in the levels of Endothelin (ET) which further induces HIF1A mRNA expression.
T215 1984-2144 Sentence denotes High VEGF expression allows the pulmonary vascular albumin extravasation which leads to the vascular permeability (Carpenter et al., 2005;Hicklin et al., 2005).
T216 2145-2349 Sentence denotes HIF1A along with AKT1 are indicated to be upregulated by viral entry mediated by endocytosis, import/export and translation of viral mRNA which is fundamental for their multiplication (Cava et al., 2020).
T217 2350-2713 Sentence denotes HIF1A activators may be used for relieving the symptoms of SARS-CoV-2 as it is responsible for the upregulation of glycolytic genes like phosphoglycerate kinase (PGK) and lactate dehydrogenase A (LDHA) under hypoxic conditions which help the tissues to adapt to oxygen deprived conditions and resort to anaerobic ATP formation (Hu et al., 2003; Lee et al., 2019).
T218 2714-2859 Sentence denotes Oxidative stress induces AkT inactivation which eventually reduces HIF1A and VEGFA levels in the body causing lung impairment (Lee et al., 2019).
T219 2860-2987 Sentence denotes Hence, compounds with Akt activating properties can be used to alleviate oxygen tension and improve the symptoms of SARS-CoV-2.
T220 2988-3214 Sentence denotes BiNGO analysis of cytoscape generated protein networks helped to understand the role of major hub nodes in understanding the pathology of SARS-CoV-2 and hence could be used as druggable targets for the treatment of SARS-CoV-2.