LitCovid-sentences  

PMC:7605643 / 33361-35428 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T187 0-146 Sentence denotes In order to come up with the medications to manage SARS-CoV-2 infections, it is important to understand the virus-receptor recognition mechanisms.
T188 147-275 Sentence denotes WHO has declared COVID-19 as a global pandemic and no drug or antiviral treatment has yet been formulated to combat the disease.
T189 276-461 Sentence denotes Hence, repurposing drugs available for other diseases could be a potential treatment strategy against SARS-CoV-2 and can be processed further for COVID-19 trials (Rosa & Santos, 2020) .
T190 462-629 Sentence denotes SARS-CoV-2 is known to affect lung alveolar epithelial cells via the angiotensin-converting enzyme II (ACE2) as an entry receptor, using receptor-mediated endocytosis.
T191 630-740 Sentence denotes ACE2 (Angiotensin converting enzyme 2) is an important player in mediating the viral entry into the host cell.
T192 741-941 Sentence denotes ACE2 is expressed in GI tract, endocrine tissues, kidneys, liver/gall bladder, testis and to smaller extents in lungs and is known to regulate cardiovascular functions, renal functions, and fertility.
T193 942-1136 Sentence denotes The newly conferred function for ACE2 is, it being a receptor for the S-protein i.e. spikes glycoprotein of all the human coronavirus such as SARS-CoV, HCoV-NL63 and SARS-CoV-2 (COVID-19 virus).
T194 1137-1296 Sentence denotes The Receptor Binding Domain (RBD) of spike proteins and ACE2 receptors come in direct contact and initiate fusion with cell membrane (Kim, 2020; Robson, 2020).
T195 1297-1481 Sentence denotes Since this interaction is essential for SARS-CoV-2 entry into the host cell and infection, this S-RBD–ACE2 interface can be the main target for vaccine developers (Shang et al., 2020).
T196 1482-1638 Sentence denotes Also, most importantly the next proteins in the signaling pathway after attachment of S-RBD-ACE2 will decide the fate of the infection and severity in body.
T197 1639-1774 Sentence denotes The information about disturbed signaling pathways in COVID-19 is of utmost importance as this can guide the route and treatment plans.
T198 1775-1911 Sentence denotes It is well known that attachment of virus to the receptor protein releases signals which help the virus to replicate and spread in body.
T199 1912-2067 Sentence denotes Therefore, a protein interaction network was sketched around ACE2 to decipher the pathways which will be impacted instantly when virus will attach to ACE2.