| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T207 |
0-162 |
Sentence |
denotes |
Most alanine substitutions exhibited similar or lower total binding affinities to nCOV-2019, however a few mutants had higher binding affinity than the wild type. |
| T208 |
163-293 |
Sentence |
denotes |
Mutant Y489A had a total binding energy of −61.78 ± 2.59 kcal/mol which was about 11 kcal/mol lower than wild type binding energy. |
| T209 |
294-391 |
Sentence |
denotes |
Mutants G446A, G447A, and T478I also demonstrated higher total binding affinities than nCOV-2019. |
| T210 |
392-477 |
Sentence |
denotes |
Other alanine substitutions had similar or lower total binding energy than nCOV-2019. |
| T211 |
478-593 |
Sentence |
denotes |
Mutant G502A has the lowest binding affinity among all the mutants with a binding energy of −24.31 ± 2.98 kcal/mol. |
| T212 |
594-739 |
Sentence |
denotes |
Mutant systems K417A, L455A, T500A, and N501A are the other mutants with total binding affinities significantly lower than the wild type complex. |
| T213 |
740-848 |
Sentence |
denotes |
The electrostatic component of binding contributes the most to the low binding affinities for these mutants. |
| T214 |
849-975 |
Sentence |
denotes |
The contribution of RBM residues to binding with ACE2 for nCOV-2019 was mapped to the RBD structure and is shown in Figure 9B. |
