| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T431 |
0-159 |
Sentence |
denotes |
The activity of mTOR depends mainly on the bioavailability of essential amino acids in addition to many other molecules in the cellular microenvironment [136]. |
| T432 |
160-470 |
Sentence |
denotes |
Evidence from preclinical and human studies confirms that ingestion of essential amino acids increases their cellular bioavailability, which is associated with upregulation of the activity of the nutrient sensing mTORC1 kinase following its translocation from the cytosol to the surface of lysosomes [135,136]. |
| T433 |
471-710 |
Sentence |
denotes |
Research shows that ingestion of small amounts of essential amino acids (6.8 g) by healthy older adults could stimulate muscle protein synthesis by activating mTORC1 signaling even without involvement in resistance exercise training [137]. |
| T434 |
711-808 |
Sentence |
denotes |
Other factors affect the capacity of essential amino acids to stimulate muscle protein synthesis. |
| T435 |
809-1069 |
Sentence |
denotes |
Amino acid bioavailability depends to a great extent on the bacterial strains of resident gut microbiome, which can either promote amino acid loss by degrading them or substantially contribute to their availability by producing some of them e.g., lysine [152]. |
| T436 |
1070-1251 |
Sentence |
denotes |
Furthermore, amino acid supplements in old age do not enhance muscle protein metabolism, combat anabolic resistance, or improve muscle condition under sedentary conditions [25,166]. |
