LitCovid-sentences  

PMC:7601109 / 58925-62907 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T351 0-4 Sentence denotes 4.8.
T352 5-26 Sentence denotes Neuronal Regeneration
T353 27-173 Sentence denotes Neuronal denervation is a key factor that contributes to skeletal muscle loss, and it is related to a plethora of pathological conditions [3,149].
T354 174-331 Sentence denotes Experimental induction of oxidative stress and inflammation results in skeletal muscle atrophy through induction of denervation e.g., of sciatic nerve [150].
T355 332-475 Sentence denotes Injuries of peripheral nerves (e.g., sciatic nerve) interrupt mechanical transmission and microvasculation of the nerve and induce reperfusion.
T356 476-680 Sentence denotes Reperfusion involves pooling of oxygen and nutrients promoting high emission of free radicals, which attack protein and lipid contents surrounding the injury site resulting in excessive tissue loss [113].
T357 681-907 Sentence denotes Likewise, alterations in gut microbiome in aged rats are associated with alterations in serum level of vitamin B12 and fat metabolism as well as reductions in the gastrocnemius muscle mass and sciatic response amplitude [151].
T358 908-1065 Sentence denotes Furthermore, dysregulation of insulin-mediated GLUT4 activity in certain areas of the central nervous system impairs neuronal metabolism and plasticity [69].
T359 1066-1321 Sentence denotes Meanwhile, activation of PGC-1α, a core regulator of mitochondrial content and oxidative metabolism, increases muscle fiber resistance to denervation and atrophy through downregulation of two ubiquitin-ligases involved in the ubiquitin-proteasome pathway:
T360 1322-1350 Sentence denotes MuRF1 and Atrogin-1 [1,152].
T361 1351-1521 Sentence denotes Propolis treatment for four weeks restored gastrocnemius muscle weight and improved functional performance (e.g., walking) in rats with crush injury of the sciatic nerve.
T362 1522-1722 Sentence denotes Effects of propolis were associated with increased nerve healing and regeneration as depicted by faster healing of the myelin sheath and ultra-structurally normal unmyelinated axons and Schwann cells.
T363 1723-1976 Sentence denotes Investigations of motor conduction from the sciatic nerve to the gastrocnemius muscle indicated that nerve recovery induced by propolis treatment promoted optimal physical functioning by allowing motor conduction to reach the gastrocnemius muscle [113].
T364 1977-2063 Sentence denotes Neuroprotective effects of propolis in motor neurons are documented in the literature.
T365 2064-2326 Sentence denotes Both kaempferide and kaempferol protected motor neurons against atrophy induced by the toxic copper-zinc superoxide dismutase in amyotrophic lateral sclerosis—a serious neurodegenerative disease that involves selective and progressive loss of motor neurons [65].
T366 2327-2763 Sentence denotes In addition, orally administered chrysin (a flavonoid that is copious in propolis) to rats intoxicated by 6-hydroxidopamine showed neuroprotective effects by mitigating neuroinflammation, enhancing levels of neurotrophins and neuronal recovery factors (e.g., brain derived neurotrophic factor and glial cell line-derived neurotrophic factor), and maintaining integrity of dopaminergic neurons resulting in better motor performance [72].
T367 2764-2994 Sentence denotes The release of acetylcholine (a neurotransmitter that regulates cognition) at the synaptic cleft of the neuromuscular junction is essential for motor neurotransmission, which controls excitation-contraction coupling and cell size.
T368 2995-3123 Sentence denotes However, free radicals, cytokines, and AGEs impair neurotransmission by altering the production of acetylcholine [6,21,149,153].
T369 3124-3216 Sentence denotes On the other hand, upregulation of acetylcholine receptors improves neurotransmission [154].
T370 3217-3342 Sentence denotes Treatment with royal jelly may correct acetylcholine neurotransmission given its high content of acetylcholine (4–8 mM) [60].
T371 3343-3583 Sentence denotes In addition, royal jelly, propolis, and bee pollen are rich in antioxidant elements that have a potential to scavenge ROS and mitigate other pathologies that contribute to acetylcholine deficiency (e.g., neuroinflammation) [73,101,102,103].
T372 3584-3890 Sentence denotes In this respect, treatment of experimental models of carrageenan-induced hind paw edema with hydroalcoholic extract of red propolis and its biomarker, formononetin, is reported to inhibit leukocyte migration and ameliorate inflammatory neurogenic pain induced by injections of formalin and glutamate [115].
T373 3891-3982 Sentence denotes However, investigations of the action of bee products on neurotransmission are very scarce.