LitCovid-sentences  

PMC:7601109 / 56281-58923 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T334 0-4 Sentence denotes 4.7.
T335 5-35 Sentence denotes Counteracting Glycation Stress
T336 36-300 Sentence denotes Oxidative stress, inflammation, and insensitivity to insulin, which accompany advanced age, contribute to the production of advanced glycation end products (AGEs) via enhancement of the activity of the Receptor for Advanced Glycation End products (RAGE) [144,145].
T337 301-482 Sentence denotes AGEs destroy the protein and lipid ingredients of muscle tissues by promoting the production of destructive molecules such as free radicals and inflammatory cytokines [101,102,113].
T338 483-597 Sentence denotes Thanks to their potent antioxidant properties, polyphenolic compounds exert multifaceted anti-glycation functions.
T339 598-794 Sentence denotes On one hand, they scavenge free-radicals and chelate transition metals that are involved in the synthesis of dicarbonyl intermediates subsequently resulting in inhibition of the formation of AGEs.
T340 795-1019 Sentence denotes On the other hand, polyphenolic compounds antagonize AGE receptors, mainly RAGE, and facilitate the removal of already formed a,b-dicarbonyl intermediates such as methylglyoxal, promoting the degradation of AGEs [37,38,146].
T341 1020-1157 Sentence denotes Royal jelly is reported to downregulate the activity of RAGE, the main receptor for AGEs, in an aged model of cognitive impairment [147].
T342 1158-1242 Sentence denotes However, its anti-glycation effect has not been investigated in skeletal muscle yet.
T343 1243-1385 Sentence denotes Propolis exhibits strong anti-AGE properties, which are superior to those of quercetin or chlorogenic acid, well-known natural AGE inhibitors.
T344 1386-1490 Sentence denotes Its flavonoid fraction potently impedes the synthesis of AGEs by trapping dicarbonyl intermediates [37].
T345 1491-1745 Sentence denotes Table 1 shows that propolis accelerated AGEs clearance in a model of muscle aging induced by administration of a precursor of AGEs (methylglyoxal) via activation of glyoxalase 1, an enzyme that eliminates dicarbonyl compounds (key elements of AGEs) [38].
T346 1746-1950 Sentence denotes CAPE inhibited the production of AGEs-related molecules such as protein carbonyl in the gastrocnemius muscle of rats via blockage of the activity of xanthine oxidase and adenosine deaminase [101,102,103].
T347 1951-2118 Sentence denotes The latter negatively affects insulin signaling and promotes the development of hyperglycemia, which represents a favorable condition for the production of AGEs [148].
T348 2119-2295 Sentence denotes However, propolis could not counteract the wasting effects of AGEs that already occurred in the extensor digitorum longus muscle though it tended to restore soleus muscle mass.
T349 2296-2439 Sentence denotes This finding denotes that different muscle tissues respond differently to treatment, probably based on their ratio of type I to type II fibers.
T350 2440-2642 Sentence denotes It also signifies the importance of early use of bee products (e.g., propolis) for the prevention of AGEs formation in skeletal muscle in people with high risk for AGEs formation such as diabetics [38].