| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T327 |
0-171 |
Sentence |
denotes |
Reduction of the number and functional capacity of the muscle satellite cells is considered a core contributor to the development of age-related muscular dysfunction [96]. |
| T328 |
172-351 |
Sentence |
denotes |
Induction of myogenesis via in vivo reprogramming of muscle satellite cells is a currently studied strategy that has not been successfully used for sarcopenia treatment yet [143]. |
| T329 |
352-612 |
Sentence |
denotes |
On the other hand, treating sarcopenic rats with both royal jelly and pRJ was reported to increase the number of Pax7-positive satellite cells in vivo and in vitro (pRJ only). pRJ induced self-renewal of satellite cells via activation of AKT signaling [96,97]. |
| T330 |
613-714 |
Sentence |
denotes |
AKT activity was associated with activation of IGF-1 as indicated by increased serum levels of IGF-1. |
| T331 |
715-1008 |
Sentence |
denotes |
IGF-1 plays a crucial rule in the activation of various signaling pathways; it is believed to be a major mediator of muscle growth and repair that functions by stimulating the proliferation and differentiation of satellite cells into myotubes, albeit the exact mechanism is not clear yet [96]. |
| T332 |
1009-1243 |
Sentence |
denotes |
Similarly, pRJ activated AKT-signaling pathway in satellite cells culture, which was associated with increased proliferation of myosatellite cells and their differentiation into myotubes—an effect that is contradictory to muscle loss. |
| T333 |
1244-1353 |
Sentence |
denotes |
AKT is thought to contribute to the synthesis of muscular proteins and inhibition of muscle proteolysis [96]. |
