PMC:7600245 / 95443-96677 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T787 0-65 Sentence denotes Therapy Type Mechanism No. of Interventional Clinical Trials b
T788 66-145 Sentence denotes Tocilizumab(Actemra) Humanized monoclonal antibody IL-6 receptor blocker ~41
T789 146-209 Sentence denotes Ruxolitinib(Jakafi) Small molecule JAK 1 and 2 inhibitor ~15
T790 210-318 Sentence denotes Colchicine(Colcrys) Small molecule Inhibition of NLRP3 inflammasome and of microtubule polymerization ~15
T791 319-415 Sentence denotes Anakinra(Kineret) Recombinant non-glycosylated human polypeptide IL-1 receptor antagonist ~13
T792 416-590 Sentence denotes Methylprednisolone (DEPOMedrol) Small molecule Intracellular receptor-mediated gene expression & suppression of migration of polymorphonuclear leukocytes, among others ~13
T793 591-656 Sentence denotes Baricitinib(Olumiant) Small molecule JAK 1 and 2 inhibitor ~12
T794 657-730 Sentence denotes Sarilumab(Kevzara) Human monoclonal antibody IL-6 receptor blocker ~10
T795 731-973 Sentence denotes Dexamethasone(Decadron, Active Injection D) Small molecule Stimulation of glucocorticoid receptors, suppression of neutrophil migration, suppression of inflammatory mediators production, and reversal of increased capillary permeability ~10
T796 974-1037 Sentence denotes Sirolimus(Rapamune) Small molecule mTOR pathway inhibitor ~4
T797 1038-1106 Sentence denotes Mavrilimumab Human monoclonal antibody GM-CSF receptor blocker ~4
T798 1107-1171 Sentence denotes Siltuximab(Sylvant) Chimeric monoclonal antibody Anti-IL-6 ~2
T799 1172-1234 Sentence denotes Canakinumab(Ilaris) Human monoclonal antibody Anti-IL-1β ~2