LitCovid-sentences  

PMC:7600245 / 82085-83627 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T645 0-60 Sentence denotes The life cycle of SARS-CoV-2 can be divided into two phases.
T646 61-170 Sentence denotes On the one hand, events prior to the viral RNA replication represent the early stage of the virus life cycle.
T647 171-397 Sentence denotes This stage involves the binding of the virus to the host cell receptor, its membrane fusion with the host cell membrane, clathrin-mediated endocytosis, and the release of the viral genome into the host cytoplasmic environment.
T648 398-528 Sentence denotes On the other hand, events that involve RNA replication and subsequent processes represent the later stage of the virus life cycle.
T649 529-677 Sentence denotes Specifically, it entails the RNA replication process, viral protein synthesis and processing, and viral particle assembly, and mature virus release.
T650 678-787 Sentence denotes Notably, events in the two phases are mediated by several interactions among various viral and host proteins.
T651 788-921 Sentence denotes For example, the viral entry is initially mediated by interactions between the viral spike S protein and the host cell receptor ACE2.
T652 922-1024 Sentence denotes Furin, TMPRSS2, and cathepsin L enzymes are also important for the early stage of the viral infection.
T653 1025-1178 Sentence denotes Importantly, the later stage of the viral life cycle involves a different set of virus–host interactions that are mediated by a different set of enzymes.
T654 1179-1419 Sentence denotes For example, the virus genetic material replication is catalyzed by RdRp and requires nucleotides that are provided by the host cell and biosynthesized by enzymes such as inosine monophosphate dehydrogenase and dihydroorotate dehydrogenase.
T655 1420-1542 Sentence denotes Furthermore, the resulting viral proteins require further processing which takes place by the action of by Mpro and PLpro.