| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T627 |
0-89 |
Sentence |
denotes |
Lactoferrin is another macromolecule that is being considered in the context of COVID-19. |
| T628 |
90-230 |
Sentence |
denotes |
It is an iron-binding, multifunctional globular glycoprotein that is widely present in secretory biological fluids, particularly milk [294]. |
| T629 |
231-340 |
Sentence |
denotes |
Lactoferrin exhibits a broad-spectrum antimicrobial activity against bacterial, viral, and fungal infections. |
| T630 |
341-494 |
Sentence |
denotes |
It also appears to exhibit a clinically relevant activity against some forms of cancer [295], cystic fibrosis [296], and necrotizing enterocolitis [297]. |
| T631 |
495-752 |
Sentence |
denotes |
Literature indicates that lactoferrin exhibits activity against a wide range of RNA and DNA viruses, including cytomegalovirus, herpes simplex viruses, HIV, HCV, poliovirus, hantaviruses, rotaviruses, human respiratory syncytial virus, and others [298,299]. |
| T632 |
753-828 |
Sentence |
denotes |
Importantly, lactoferrin also appears to exhibit activity against SARS-CoV. |
| T633 |
829-913 |
Sentence |
denotes |
It was shown that lactoferrin prevented SARS-CoV from entering human cultured cells. |
| T634 |
914-1136 |
Sentence |
denotes |
Lactoferrin appeared to block the interaction between the viral spike S protein and heparan sulfate proteoglycans, which serve as an anchoring site on the host cell surface during the early phase of virus infections [300]. |
| T635 |
1137-1305 |
Sentence |
denotes |
Lactoferrin was also found to support the growth of the gut flora as well as the enterocytes proliferation with direct anti-inflammatory/immunomodulatory effects [301]. |
| T636 |
1306-1532 |
Sentence |
denotes |
Currently, lactoferrin is being tested in few clinical trials for COVID-19, including liposomal lactoferrin in COVID-19 patients with mild-to-moderate disease as well as in asymptomatic COVID-19 patients (NCT04475120; n = 60). |
