LitCovid-sentences  

PMC:7600245 / 75952-78492 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T593 0-5 Sentence denotes 4.21.
T594 6-20 Sentence denotes Poly-Alcohols:
T595 21-46 Sentence denotes Resveratrol and Quercetin
T596 47-133 Sentence denotes On the one hand, resveratrol is a natural polyphenolic stilbene derivative (Figure 9).
T597 134-283 Sentence denotes Resveratrol exhibits several biological activities, including antioxidant, antitumor, anti-inflammatory, oxygen scavenging, and antiviral activities.
T598 284-364 Sentence denotes Resveratrol inhibits TNF-induced activation of NF-κB in a dose-dependent manner.
T599 365-434 Sentence denotes Furthermore, it inhibits cyclooxygenase and hydro-peroxidase enzymes.
T600 435-559 Sentence denotes Not only that but it also inhibits vascular cell adhesion molecule expression and vascular smooth muscle cell proliferation.
T601 560-691 Sentence denotes It also stimulates endothelial nitric oxide synthase activity and inhibits platelet aggregation and LDL peroxidation [276,277,278].
T602 692-778 Sentence denotes All these effects are expected to help fight COVID-19 infection and its complications.
T603 779-904 Sentence denotes Importantly, resveratrol significantly inhibited MERS-CoV replication in vitro mainly by inhibiting the RNA production [279].
T604 905-1007 Sentence denotes Resveratrol also inhibited the replication of duck enteritis virus [280] and pseudorabies virus [281].
T605 1008-1193 Sentence denotes Accordingly, the safety and efficacy of resveratrol in COVID-19 patients are being tested in a randomized double-blind, placebo-controlled proof-of-concept trial (NCT04400890; n = 200).
T606 1194-1276 Sentence denotes On the other hand, quercetin is a natural penta-hydroxylated flavonoid (Figure 9).
T607 1277-1401 Sentence denotes Similar to resveratrol, quercetin possesses antioxidant, oxygen scavenging, anti-inflammatory, and cardioprotective effects.
T608 1402-1520 Sentence denotes Quercetin also inhibits platelet aggregation and lipid peroxidation and affects the function of several kinases [282].
T609 1521-1621 Sentence denotes Importantly, quercetin also exhibits a wide spectrum antiviral activity against DNA and RNA viruses.
T610 1622-1701 Sentence denotes For example, quercetin inhibited several respiratory viruses in cultured cells.
T611 1702-1822 Sentence denotes It also inhibited the cytopathic effects of rhinoviruses, echoviruses, coxsackieviruses, and polioviruses [283,284,285].
T612 1823-1976 Sentence denotes Quercetin also significantly reduced plaque formation by polio virus, herpes simplex virus 1, respiratory syncytial virus, and parainfluenza virus [286].
T613 1977-2070 Sentence denotes Furthermore, quercetin inhibited the replication of cytomegalovirus and dengue virus 2 [287].
T614 2071-2238 Sentence denotes The antiviral effects of quercetin are thought to be because it either blocks the virus entry or inhibits the viral replication enzymes, i.e., viral polymerases [288].
T615 2239-2322 Sentence denotes Other flavonoids have recently been reported as potential inhibitors of Mpro [289].
T616 2323-2457 Sentence denotes Accordingly, the effect of quercetin alone as a prophylactic or as a treatment is being tested in COVID-19 patients (NCT04377789; 50).
T617 2458-2540 Sentence denotes It is also being tested with zinc, bromelain, and vitamin C (NCT04468139; n = 60).