LitCovid-sentences  

PMC:7600245 / 73272-74869 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T574 0-100 Sentence denotes Nitric oxide is an endogenous signaling molecule that is involved in a host of biological processes.
T575 101-229 Sentence denotes The molecule is produced internally by the action of nitric oxide synthase enzyme that catalyzes its production from L-arginine.
T576 230-482 Sentence denotes The antimicrobial activity of nitric oxide has been described against several protozoal and bacterial pathogens as well as against some viruses (herpes simplex virus 1, neurotropic murine coronavirus, and murine hepatitis virus strain 3) [267,268,269].
T577 483-637 Sentence denotes The role of nitric oxide in SARS-CoV infection was earlier investigated in Vero E6 cells by using the nitric oxide donor S-nitroso-N-acetyl-penicillamine.
T578 638-785 Sentence denotes The study revealed that the nitric oxide donor substantially inhibited the replication of SARS-CoV in a concentration-dependent fashion (0–400 µM).
T579 786-845 Sentence denotes Nitric oxide inhibited the viral protein and RNA synthesis.
T580 846-988 Sentence denotes Importantly, the study demonstrated that nitric oxide produced by inducible nitric oxide synthase inhibited the replication of SARS-CoV [270].
T581 989-1100 Sentence denotes Another study revealed that nitric oxide causes a reduction in the palmitoylation of the viral spike S protein.
T582 1101-1190 Sentence denotes This subsequently impedes the fusion between the viral spike S protein and the host ACE2.
T583 1191-1321 Sentence denotes Moreover, nitric oxide also leads to a substantial decrease in viral RNA production in the early steps of viral replication [271].
T584 1322-1421 Sentence denotes These outcomes were attributed to its potential effect on the cysteine proteases of SARS-CoV [272].
T585 1422-1597 Sentence denotes Given that the genome of SARS-CoV is significantly similar to SARS-CoV-2, the inhaled nitric oxide therapy in COVID-19 patients is predicted to produce the same effects [273].