LitCovid-sentences  

PMC:7600245 / 71493-73243 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T556 0-5 Sentence denotes 4.19.
T557 6-33 Sentence denotes Methylene Blue (ProvayBlue)
T558 34-132 Sentence denotes Methylene blue is disubstituted phenothiazine derivative (Figure S6) that was approved by the U.S.
T559 133-187 Sentence denotes FDA for the parenteral treatment of methemoglobinemia.
T560 188-247 Sentence denotes It acts by forming leukomethylene blue complex within RBCs.
T561 248-345 Sentence denotes The product is a reducing agent that converts the ferric ion back to the ferrous ion state [256].
T562 346-410 Sentence denotes Methylene blue has antiviral activity [257,258,259,260,261,262].
T563 411-592 Sentence denotes A recent study showed that photochemical treatment in conjunction with methylene blue can be used to inactivate SARS-CoV-2 for blood safety and in convalescent plasma therapy [257].
T564 593-745 Sentence denotes Methylene blue is also known to kill coronavirus (specifically SARS-CoV-2) and HIV in the blood supply when combined with photo-biomodulation [258,259].
T565 746-987 Sentence denotes Methylene blue and UV/visible light have also been reported to inactivate different viruses, in plasma and in platelet concentrates, including SARS-CoV, MERS-CoV, Ebola virus, Crimean-Congo hemorrhagic fever virus, and Nipah virus [260,261].
T566 988-1114 Sentence denotes A mice model study also demonstrated the ability of methylene blue plus fluorescent light to inactivate West Nile Virus [262].
T567 1115-1163 Sentence denotes It is also effective against septic shock [263].
T568 1164-1323 Sentence denotes Furthermore, methylene blue is a potent inhibitor of guanylate cyclase, and thus, it improves the arterial pressure and cardiac function in septic shock [264].
T569 1324-1460 Sentence denotes It also improves systemic vascular resistance and mean arterial pressure while decreases vasopressor requirements in septic shock [265].
T570 1461-1567 Sentence denotes It also demonstrates anti-inflammatory effects because it can inhibit NLRP3 inflammasome activation [266].
T571 1568-1750 Sentence denotes The drug is currently being tested in the context of COVID-19 in a few trials alone (NCT04376788; n = 15) or in combination with vitamin C and N-acetylcysteine (NCT04370288; n = 20).