LitCovid-sentences  

PMC:7600245 / 69974-71491 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T544 0-5 Sentence denotes 4.18.
T545 6-29 Sentence denotes Chlorhexidine (Peridex)
T546 30-152 Sentence denotes Chlorhexidine is a broad-spectrum, guanidino-containing antimicrobial agent (Figure S6) that is widely used as antiseptic.
T547 153-240 Sentence denotes It was first approved in the U.S. in 1986 and is used for gingivitis and periodontitis.
T548 241-367 Sentence denotes It is also used for the oropharyngeal sanitization to reduce the risk of ventilator-associated or hospital-acquired pneumonia.
T549 368-436 Sentence denotes It is used as a skin disinfectant for preoperative skin preparation.
T550 437-588 Sentence denotes It can also be used to disinfect hands, surface wounds, surgical tools, and surgical scrub, for both patients and healthcare workers [252,253,254,255].
T551 589-692 Sentence denotes Mechanistically, it has both micro-biostatic and micro-biocidal effects depending on its concentration.
T552 693-935 Sentence denotes The former effect happens at low concentrations due to the binding of this cationic molecule to the negatively charged extracellular components of some microbes, which causes an alteration of osmotic equilibrium and leakage of essential ions.
T553 936-1093 Sentence denotes At higher concentrations, the molecule gets into the microbial cells and precipitates intracellular components, leading to microbial death [252,253,254,255].
T554 1094-1338 Sentence denotes Currently, 0.12% chlorhexidine oral/nasal rinse is being tested in a randomized, open-label, single-institution study so as to evaluate its potential to reduce oro- and naso-pharyngeal viral load in patients with COVID-19 (NCT04344236; n = 48).
T555 1339-1517 Sentence denotes Recently, computational methods have proposed chlorhexidine to be an inhibitor of 3CLpro and/or RdRp of SARS-CoV-2 [169], yet this potential is to be experimentally demonstrated.