LitCovid-sentences  

PMC:7600245 / 60946-62893 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T462 0-5 Sentence denotes 4.11.
T463 6-29 Sentence denotes Deferoxamine (Desferal)
T464 30-110 Sentence denotes Deferoxamine (Figure S5) is a natural chelating agent from Streptomyces pilosus.
T465 111-144 Sentence denotes It was first approved by the U.S.
T466 145-211 Sentence denotes FDA in 1968 and has been parenterally used to treat iron toxicity.
T467 212-367 Sentence denotes The drug complexes with the ferric ion, primarily in the vascular space, to form ferrioxamine complex that gets subsequently eliminated in urine [201,202].
T468 368-449 Sentence denotes There are reports about unusually high serum ferritin in COVID-19 patients [203].
T469 450-600 Sentence denotes A retrospective, multicenter cohort study reported increased levels of serum ferritin in COVID-19 non-survivors compared with COVID-19 survivors [99].
T470 601-729 Sentence denotes The increase in serum ferritin indicates dysregulated iron homeostasis pertaining to oxidative stress and inflammatory response.
T471 730-920 Sentence denotes Dysregulated iron homeostasis may propagate the viral infections leading to severe respiratory illnesses such as pulmonary fibrosis and acute respiratory distress syndrome [204,205,206,207].
T472 921-1042 Sentence denotes Accordingly, the use of iron chelators, particularly deferoxamine, in managing/treating COVID-19 has been proposed [208].
T473 1043-1257 Sentence denotes Deferoxamine may exert an antiviral effect by depleting iron availability, which has been shown to play a critical role in the replication of RNA viruses such as HCV, HIV, and West Nile virus [209,210,211,212,213].
T474 1258-1364 Sentence denotes In addition to its effect on iron level, deferoxamine also appears to have immunomodulatory effects [209].
T475 1365-1482 Sentence denotes Along these lines, deferoxamine mitigated the symptoms of Enterovirus-infected mice and decreased the mortality rate.
T476 1483-1572 Sentence denotes It also upregulated the B cell levels and improved the neutralizing antibody titer [209].
T477 1573-1720 Sentence denotes Deferoxamine has also been reported to in vitro block endothelial inflammation induced by influenza A infection by inhibiting IL-6 synthesis [214].
T478 1721-1769 Sentence denotes Deferoxamine may also have antifibrotic effects.
T479 1770-1947 Sentence denotes An intranasal treatment with deferoxamine was reported to prevent pulmonary fibrosis and pulmonary functional decline in bleomycin-induced pulmonary fibrosis animal model [206].