| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T445 |
0-100 |
Sentence |
denotes |
Cyclosporine A is a cyclic peptide that is naturally obtained from the fungus Beauveria nivea [191]. |
| T446 |
101-189 |
Sentence |
denotes |
It is immunosuppressant and calcineurin inhibitor that inhibits T cell activation [192]. |
| T447 |
190-288 |
Sentence |
denotes |
It binds to the intracellular receptor cyclophilin-1 producing a cyclosporine-cyclophilin complex. |
| T448 |
289-459 |
Sentence |
denotes |
This complex subsequently inhibits calcineurin, which stops the activation of the nuclear factor of activated T cells (NF-AT) that normally causes inflammatory reactions. |
| T449 |
460-593 |
Sentence |
denotes |
The inhibition of NF-AT also leads to lower levels of other factors associated with T helper cell function and thymocyte development. |
| T450 |
594-637 |
Sentence |
denotes |
Cyclosporine was first approved by the U.S. |
| T451 |
638-906 |
Sentence |
denotes |
FDA in 1983 and is orally, parenterally, or topically used to prevent organ transplant rejection, treat/prevent graft-versus-host disease, and treat various inflammatory and autoimmune conditions such as severe rheumatoid arthritis and psoriasis [191,192,193,194,195]. |
