LitCovid-sentences  

PMC:7600245 / 58682-60944 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T443 0-5 Sentence denotes 4.10.
T444 6-30 Sentence denotes Cyclosporine A (Gengraf)
T445 31-131 Sentence denotes Cyclosporine A is a cyclic peptide that is naturally obtained from the fungus Beauveria nivea [191].
T446 132-220 Sentence denotes It is immunosuppressant and calcineurin inhibitor that inhibits T cell activation [192].
T447 221-319 Sentence denotes It binds to the intracellular receptor cyclophilin-1 producing a cyclosporine-cyclophilin complex.
T448 320-490 Sentence denotes This complex subsequently inhibits calcineurin, which stops the activation of the nuclear factor of activated T cells (NF-AT) that normally causes inflammatory reactions.
T449 491-624 Sentence denotes The inhibition of NF-AT also leads to lower levels of other factors associated with T helper cell function and thymocyte development.
T450 625-668 Sentence denotes Cyclosporine was first approved by the U.S.
T451 669-937 Sentence denotes FDA in 1983 and is orally, parenterally, or topically used to prevent organ transplant rejection, treat/prevent graft-versus-host disease, and treat various inflammatory and autoimmune conditions such as severe rheumatoid arthritis and psoriasis [191,192,193,194,195].
T452 938-1125 Sentence denotes Importantly, low micromolar concentrations of cyclosporin A (<35 µM) substantially impacted the replication of SARS-CoV, human coronavirus 229E, and mouse hepatitis virus in cell culture.
T453 1126-1207 Sentence denotes Cyclosporin A significantly inhibited gene expression and reduced progeny titers.
T454 1208-1292 Sentence denotes Cyclosporin A treatment completely blocked SARS-CoV RNA and protein synthesis [196].
T455 1293-1464 Sentence denotes Cyclosporine A also in vitro reduced the replication of MERS-CoV, transmissible gastroenteritis coronavirus, porcine epidemic diarrhea virus, and feline coronavirus [196].
T456 1465-1539 Sentence denotes In fact, cyclosporine A has demonstrated broad-spectrum antiviral effects.
T457 1540-1596 Sentence denotes It inhibited the replication of HBV, HCV, and HIV [197].
T458 1597-1842 Sentence denotes Cyclosporine also inhibited the replication of Zika virus, West Nile virus, Rift Valley fever virus, and influenza A virus by blocking the interaction of cellular cyclophilins with viral proteins as well as by inhibiting the RNA synthesis [198].
T459 1843-1920 Sentence denotes By targeting cyclophilins, the drug can also prevent acute lung injury [199].
T460 1921-2202 Sentence denotes Currently, the use of cyclosporin A is being tested in patients with moderate COVID-19 (NCT04412785; n = 20), hospitalized COVID-19 patients (NCT04392531; n = 120), and combined with topical corticosteroid in COVID-19 patients with acute keratoconjunctivitis (NCT04451239; n = 12).
T461 2203-2262 Sentence denotes It has also been used in psoriatic COVID-19 patients [200].