| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T436 |
0-4 |
Sentence |
denotes |
4.9. |
| T437 |
5-26 |
Sentence |
denotes |
Plitidepsin (Aplidin) |
| T438 |
27-130 |
Sentence |
denotes |
It is a cyclic depsipeptide natural product (Figure S5) that is extracted from Aplidium albicans [186]. |
| T439 |
131-265 |
Sentence |
denotes |
It is used for acute lymphoblastic leukemia and, with dexamethasone, for patients with refractory and relapsed multiple myeloma [187]. |
| T440 |
266-378 |
Sentence |
denotes |
Recently, the molecule was reported to have in vitro nanomolar potency against the human coronavirus 229E [188]. |
| T441 |
379-629 |
Sentence |
denotes |
The mechanism is thought to be similar to its anticancer activity, i.e., targeting eukaryotic translation elongation factor 1-α1, which has been reported to play an unexpected role in the replication and pathogenesis of various RNA viruses [189,190]. |
| T442 |
630-720 |
Sentence |
denotes |
The drug is being tested in phase 1 trial in patients with COVID-19 (NCT04382066; n = 27). |
