| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T403 |
0-173 |
Sentence |
denotes |
It is an orally bioavailable, 3-substituted indole derivative (Figure 8A) and microtubule depolymerization agent that recognizes colchicine-binding site on tubulin subunits. |
| T404 |
174-230 |
Sentence |
denotes |
It has been under clinical development for cancer [170]. |
| T405 |
231-442 |
Sentence |
denotes |
Drugs targeting microtubules have broad antiviral activity because they disrupt the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection. |
| T406 |
443-616 |
Sentence |
denotes |
Microtubule depolymerization agents also have strong anti-inflammatory effects that can be beneficial in mitigating the cytokine storm induced by SARS-CoV-2 infection [171]. |
| T407 |
617-827 |
Sentence |
denotes |
The drug is currently being evaluated in a phase 2 randomized, placebo-controlled study for the treatment of SARS-CoV-2 in patients at elevated risk of acute respiratory distress syndrome (NCT04388826; n = 40). |
| T408 |
828-940 |
Sentence |
denotes |
Of note, it is mechanistically similar to colchicine, which has also been considered in COVID-19 patients [172]. |
