| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T383 |
0-152 |
Sentence |
denotes |
Likewise, brequinar is a synthetic, small molecule, and quinoline-carboxylic acid derivative (Figure 7) that also inhibits dihydroorotate dehydrogenase. |
| T384 |
153-241 |
Sentence |
denotes |
It eventually blocks the de novo biosynthesis of pyrimidine-based nucleotides [158,159]. |
| T385 |
242-301 |
Sentence |
denotes |
Accordingly, brequinar possesses immunosuppressive effects. |
| T386 |
302-460 |
Sentence |
denotes |
Furthermore, it also possesses antineoplastic properties that can be exploited to enhance the in vivo antitumor activity of other antineoplastic agents [160]. |
| T387 |
461-526 |
Sentence |
denotes |
Alternatively, the drug has also antiparasitic effects [160,161]. |
| T388 |
527-684 |
Sentence |
denotes |
More importantly, the drug exhibits a broad-spectrum antiviral activity against influenza viruses [162], HIV-1 [163], and foot-and-mouth disease virus [164]. |
| T389 |
685-838 |
Sentence |
denotes |
In fact, a pre-print under review has documented the activity of dihydroorotate dehydrogenase inhibitors against RNA viruses, including SARS-CoV-2 [165]. |
| T390 |
839-1022 |
Sentence |
denotes |
Currently, the drug is being evaluated in a randomized, open-label trial to assess its safety and anti-coronavirus activity in hospitalized adults with COVID-19 (NCT04425252; n = 24). |
