LitCovid-sentences  

PMC:7600245 / 49590-52711 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T369 0-4 Sentence denotes 4.4.
T370 5-71 Sentence denotes Vidofludimus Calcium (Immunic AG, IMU-838) and Brequinar (DuP-785)
T371 72-265 Sentence denotes Vidofludimus is a synthetic small molecule that is under investigation for treating inflammatory bowel disease, multiple sclerosis, and other inflammatory and autoimmune diseases [154,155,156].
T372 266-392 Sentence denotes It is a biphenyl-carbamoyl-cyclopentene derivative (Figure 7) that is being developed as oral formulation for therapeutic use.
T373 393-625 Sentence denotes Currently, a prospective, randomized, multi-center, double-blinded, and placebo-controlled study is ongoing to evaluate the safety and efficacy of vidofludimus as an adjunct therapy in COVID-19 patients (NCT04379271; n = 230) [157].
T374 626-818 Sentence denotes The investigational drug selectively inhibits dihydroorotate dehydrogenase, an important enzyme for the de novo biosynthesis of pyrimidine-based nucleotides, in activated B and T immune cells.
T375 819-939 Sentence denotes Such inhibition diminishes the pyrimidine pool in these cells, which subsequently exposes the cells to metabolic stress.
T376 940-1093 Sentence denotes It also diminishes the release of T helper 1 (Th1) and T helper 17 (Th17) proinflammatory cytokines of IL-17 and IFN-γ, which reduces inflammation [154].
T377 1094-1312 Sentence denotes Interestingly, dihydroorotate dehydrogenase inhibition also results in a direct antiviral effect, which has been exhibited in cells infected with hemorrhagic fever-causing viruses, cytomegalovirus, and influenza virus.
T378 1313-1457 Sentence denotes In fact, IMU-838′s antiviral activity has been demonstrated in vitro against arenavirus, cytomegalovirus, influenza A virus, HCV, and HIV [157].
T379 1458-1540 Sentence denotes IMU-838 has also effectively promoted antiviral activity against SARS-CoV-2 [157].
T380 1541-1624 Sentence denotes Specifically, IMU-838 inhibited the replication of clinical isolates of SARS-CoV-2.
T381 1625-1810 Sentence denotes In cellular assays, IMU-838 promoted the anti-SARS-CoV-2 activity at concentrations lower than those that have been considered in previous and ongoing clinical trials [154,155,156,157].
T382 1811-2098 Sentence denotes Overall, IMU-838′s antiviral activity against SARS-CoV-2 as well as its selective immunomodulatory effect targeting activated immune cells appear to be interesting, particularly that it potentially prevents the virus reactivation that may happen with other immunomodulatory agents [157].
T383 2099-2251 Sentence denotes Likewise, brequinar is a synthetic, small molecule, and quinoline-carboxylic acid derivative (Figure 7) that also inhibits dihydroorotate dehydrogenase.
T384 2252-2340 Sentence denotes It eventually blocks the de novo biosynthesis of pyrimidine-based nucleotides [158,159].
T385 2341-2400 Sentence denotes Accordingly, brequinar possesses immunosuppressive effects.
T386 2401-2559 Sentence denotes Furthermore, it also possesses antineoplastic properties that can be exploited to enhance the in vivo antitumor activity of other antineoplastic agents [160].
T387 2560-2625 Sentence denotes Alternatively, the drug has also antiparasitic effects [160,161].
T388 2626-2783 Sentence denotes More importantly, the drug exhibits a broad-spectrum antiviral activity against influenza viruses [162], HIV-1 [163], and foot-and-mouth disease virus [164].
T389 2784-2937 Sentence denotes In fact, a pre-print under review has documented the activity of dihydroorotate dehydrogenase inhibitors against RNA viruses, including SARS-CoV-2 [165].
T390 2938-3121 Sentence denotes Currently, the drug is being evaluated in a randomized, open-label trial to assess its safety and anti-coronavirus activity in hospitalized adults with COVID-19 (NCT04425252; n = 24).