LitCovid-sentences  

PMC:7600245 / 26472-27992 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T193 0-72 Sentence denotes It is the isopropyl-ester prodrug of β-D-N4-hydroxycytidine (Figure 5A).
T194 73-203 Sentence denotes The prodrug has improved oral bioavailability as it avoids phosphorylation of the N4-hydroxyl group in the gastrointestinal tract.
T195 204-366 Sentence denotes It is hydrolyzed in vivo to release the parent (EIDD-1931), which distributes into tissues, and upon tri-phosphorylation, it becomes the active triphosphate form.
T196 367-623 Sentence denotes The tri-phosphorylated form has a broad-spectrum antiviral activity against various RNA viruses, including influenza, Ebola, Venezuelan equine encephalitis virus, MERS-CoV, SARS-CoV, SARS-CoV-2 and related zoonotic group 2b or 2c bat coronaviruses [80,81].
T197 624-730 Sentence denotes It also demonstrated increased potency against a coronavirus with resistance mutations to remdesivir [82].
T198 731-897 Sentence denotes By the action of RdRp, the active form is incorporated into the genome of RNA viruses, leading to the accumulation of mutations known as viral error catastrophe [80].
T199 898-1080 Sentence denotes The active form exists in two forms (Figure 5B): the oxime form which mimics uridine and pairs with adenosine, while the other tautomer mimics cytidine and pairs with guanosine [81].
T200 1081-1248 Sentence denotes In mice infected with MERS-CoV or SARS-CoV, EIDD-2801 administration was found to diminish the virus titer and body weight loss and to improve pulmonary function [80].
T201 1249-1377 Sentence denotes Reduced MERS-CoV yields in vitro and in vivo was because of the increase in transition mutation frequency in only the viral RNA.
T202 1378-1445 Sentence denotes The drug produced similar results in human airway epithelial cells.
T203 1446-1520 Sentence denotes The drug showed similar results as a prophylactic and as a treatment [80].