LitCovid-sentences  

PMC:7600245 / 131-1798 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4 0-109 Sentence denotes The coronavirus disease-2019 (COVID-19) pandemic continues to challenge health care systems around the world.
T5 110-254 Sentence denotes Scientists and pharmaceutical companies have promptly responded by advancing potential therapeutics into clinical trials at an exponential rate.
T6 255-337 Sentence denotes Initial encouraging results have been realized using remdesivir and dexamethasone.
T7 338-579 Sentence denotes Yet, the research continues so as to identify better clinically relevant therapeutics that act either as prophylactics to prevent the infection or as treatments to limit the severity of COVID-19 and substantially decrease the mortality rate.
T8 580-701 Sentence denotes Previously, we reviewed the potential therapeutics in clinical trials that block the early stage of the viral life cycle.
T9 702-833 Sentence denotes In this review, we summarize potential anti-COVID-19 therapeutics that block/inhibit the post-entry stages of the viral life cycle.
T10 834-1060 Sentence denotes The review presents not only the chemical structures and mechanisms of the potential therapeutics under clinical investigation, i.e., listed in clinicaltrials.gov, but it also describes the relevant results of clinical trials.
T11 1061-1130 Sentence denotes Their anti-inflammatory/immune-modulatory effects are also described.
T12 1131-1222 Sentence denotes The reviewed therapeutics include small molecules, polypeptides, and monoclonal antibodies.
T13 1223-1360 Sentence denotes At the molecular level, the therapeutics target viral proteins or processes that facilitate the post-entry stages of the viral infection.
T14 1361-1514 Sentence denotes Frequent targets are the viral RNA-dependent RNA polymerase (RdRp) and the viral proteases such as papain-like protease (PLpro) and main protease (Mpro).
T15 1515-1667 Sentence denotes Overall, we aim at presenting up-to-date details of anti-COVID-19 therapeutics so as to catalyze their potential effective use in fighting the pandemic.