| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T70 |
0-129 |
Sentence |
denotes |
With regards to transplacental transmission of SARS-CoV-2, it is essential to understand how the virus infects cells of the body. |
| T71 |
130-254 |
Sentence |
denotes |
SARS-CoV-2 infects host cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane-bound aminopeptidase [10,11]. |
| T72 |
255-353 |
Sentence |
denotes |
This leads to receptor-mediated endocytosis of the virus, which is necessary for replication [11]. |
| T73 |
354-545 |
Sentence |
denotes |
While ACE2 is predominantly expressed in the heart, lungs, kidneys, and gastrointestinal tract, recent studies uncovered ACE2 expression in various placental tissues and fetal organs [10–12]. |
| T74 |
546-711 |
Sentence |
denotes |
While this expression is low in early gestational ages, it increases significantly in later stages of pregnancy [11], thereby increasing the risk of fetal infection. |
| T75 |
712-977 |
Sentence |
denotes |
Although similar viruses like severe acute respiratory syndrome coronavirus 1 have not demonstrated the ability to cause fetal infection, SARS-CoV-2 is able to bind ACE2 with much higher affinity [11], thus increasing the probability of transplacental transmission. |
