| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T533 |
0-205 |
Sentence |
denotes |
Another example of practical application of ssNMR is the work of Lee and colleagues [363] in which they investigated the structure of a designed zinc-binding amyloid fibril that catalyzed ester hydrolysis. |
| T534 |
206-339 |
Sentence |
denotes |
Metals ions such as zinc where found to affect the process of protein aggregation which resulted in arise of amyloid like structures. |
| T535 |
340-498 |
Sentence |
denotes |
Therefore, understanding the processes of aggregation and the factors related to them is crucial for creation of new drugs for amyloid related diseases [364]. |
| T536 |
499-627 |
Sentence |
denotes |
In the experiment Lee et al. used Ac-IHVHLQI-CONH2 peptide (referred as HHQ) to form fibrils with varying Zn2+:HHQ molar ratios. |
| T537 |
628-858 |
Sentence |
denotes |
The results showed that Zn2+-bound HHQ fibrils form parallel-in-register form of packing β-strand in each sheet and His residues are coordinated to Zn2+ via Nδ1, while half of the His residues are also coordinated to Zn2+ via Nε2. |
| T538 |
859-917 |
Sentence |
denotes |
Additionally, Zn2+ binds in a 1:1 metal ion/peptide ratio. |
| T539 |
918-1081 |
Sentence |
denotes |
After further analysis using structural bioinformatics, it was concluded that each zinc ion was coordinated by three histidine nitrogens from two adjacent strands. |
| T540 |
1082-1166 |
Sentence |
denotes |
Half of all histidines bridged to Zn2+ ions forming a metal–imidazolate chain [363]. |
