PMC:7594251 / 80404-81587 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T526 0-163 Sentence denotes An example of ssNMR application related to drug design is the work of Callari et al., who monitored the effect of drug loading on the properties of micelles [362].
T527 164-350 Sentence denotes Polymer micelles are widely used as nano-carries for drug delivery, but so far the effects of drug loading on the morphology of a drug carrier had not been thoroughly investigated [362].
T528 351-504 Sentence denotes They created a model consisting of a fructose hydrophilic block and a PMAA block (micelle), to which a different amount of platinum complex was anchored.
T529 505-662 Sentence denotes The results from this experiment showed that micelles loaded with a higher amount of platinum complex had reduced cellular uptake, release, and cytotoxicity.
T530 663-896 Sentence denotes The micelles with a lower load (LL) of platinum complex were more effective at targeting cancer cells (of cell lines MDA-MB-231 (breast cancer) and A549 (lung cancer) than the micelles with a higher load (HL) of the platinum complex.
T531 897-1030 Sentence denotes This is evidenced by the lower IC50 (half maximal inhibitory concentration) values of the LL micelles as compared to the HL micelles.
T532 1031-1183 Sentence denotes Both of those results could be related to the micellar structure and their potential for interaction between the sugar moieties and the cell wall [362].