Id |
Subject |
Object |
Predicate |
Lexical cue |
T526 |
0-163 |
Sentence |
denotes |
An example of ssNMR application related to drug design is the work of Callari et al., who monitored the effect of drug loading on the properties of micelles [362]. |
T527 |
164-350 |
Sentence |
denotes |
Polymer micelles are widely used as nano-carries for drug delivery, but so far the effects of drug loading on the morphology of a drug carrier had not been thoroughly investigated [362]. |
T528 |
351-504 |
Sentence |
denotes |
They created a model consisting of a fructose hydrophilic block and a PMAA block (micelle), to which a different amount of platinum complex was anchored. |
T529 |
505-662 |
Sentence |
denotes |
The results from this experiment showed that micelles loaded with a higher amount of platinum complex had reduced cellular uptake, release, and cytotoxicity. |
T530 |
663-896 |
Sentence |
denotes |
The micelles with a lower load (LL) of platinum complex were more effective at targeting cancer cells (of cell lines MDA-MB-231 (breast cancer) and A549 (lung cancer) than the micelles with a higher load (HL) of the platinum complex. |
T531 |
897-1030 |
Sentence |
denotes |
This is evidenced by the lower IC50 (half maximal inhibitory concentration) values of the LL micelles as compared to the HL micelles. |
T532 |
1031-1183 |
Sentence |
denotes |
Both of those results could be related to the micellar structure and their potential for interaction between the sugar moieties and the cell wall [362]. |