LitCovid-sentences  

PMC:7594251 / 71-1729 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T3 0-153 Sentence denotes Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies.
T4 154-279 Sentence denotes Microbial infections are still a major challenge because pathogens rapidly and continually evolve developing drug resistance.
T5 280-402 Sentence denotes Cancer cells also change genetically, and current therapeutic techniques may be (or may become) ineffective in many cases.
T6 403-541 Sentence denotes The pathology of many neurological diseases remains an enigma, and the exact etiology and underlying mechanisms are still largely unknown.
T7 542-862 Sentence denotes Viral infections spread and develop much more quickly than does the corresponding research needed to prevent and combat these infections; the present and most relevant outbreak of SARS-CoV-2, which originated in Wuhan, China, illustrates the critical and immediate need to improve drug design and development techniques.
T8 863-928 Sentence denotes Modern day drug discovery is a time-consuming, expensive process.
T9 929-1034 Sentence denotes Each new drug takes in excess of 10 years to develop and costs on average more than a billion US dollars.
T10 1035-1105 Sentence denotes This demonstrates the need of a complete redesign or novel strategies.
T11 1106-1232 Sentence denotes Nuclear Magnetic Resonance (NMR) has played a critical role in drug discovery ever since its introduction several decades ago.
T12 1233-1345 Sentence denotes In just three decades, NMR has become a “gold standard” platform technology in medical and pharmacology studies.
T13 1346-1458 Sentence denotes In this review, we present the major applications of NMR spectroscopy in medical drug discovery and development.
T14 1459-1561 Sentence denotes The basic concepts, theories, and applications of the most commonly used NMR techniques are presented.
T15 1562-1658 Sentence denotes We also summarize the advantages and limitations of the primary NMR methods in drug development.