LitCovid-sentences  

PMC:7594251 / 21374-23877 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T152 0-6 Sentence denotes 2.2.1.
T153 7-20 Sentence denotes 2D 1H,1H-COSY
T154 21-98 Sentence denotes COSY is one of the simplest and most frequently used 2D NMR experiment [123].
T155 99-199 Sentence denotes It shows the homonuclear coupling of nuclei (i.e., 1H-1H) separated by up to several covalent bonds.
T156 200-403 Sentence denotes The pulse sequence consists of a 90° excitation pulse followed by a specific evolution time (t1), a second pulse, and finally a measurement period (t2, not to be confused with relaxation rates or times).
T157 404-579 Sentence denotes The second pulse can be 90° or 45° or 135°, depending upon the specific requirements, and respectively yield COSY [124], COSY-45 or COSY-135 functionality (see [125,126,127]).
T158 580-748 Sentence denotes A two-dimensional Fourier Transform (FT) yields the final spectra and shows the frequencies for proton (1H) or carbon (in the case of carbon detection) along both axes.
T159 749-968 Sentence denotes There are two types of peaks; (I) Diagonal peaks, which represent the peaks of the conventional 1D spectra, and (II) cross-peaks, which have different values in the two frequency axes and are therefore off the diagonal.
T160 969-1138 Sentence denotes These off diagonal cross-peaks are the most important pieces of information as they mark correlations between pairs of nuclei due to through bond magnetization transfer.
T161 1139-1298 Sentence denotes This helps in identifying which atoms are connected [128], critical for structural elucidation of both known molecules and unknown molecules in solution [129].
T162 1299-1491 Sentence denotes By implementing phase-cycling [130,131], it is also possible to distinguish different types of coupling and yields further helpful information about the chemical structure of a molecule [132].
T163 1492-1585 Sentence denotes As an example, the use of the COSY experiment was presented in the work of Zheng et al. [88].
T164 1586-1797 Sentence denotes The main goal of their work was to investigate potential biological differences and compare the pharmacological effects between Danggui (an herbal drug used in traditional Chinese medicine) and European Danggui.
T165 1798-1932 Sentence denotes For that, Zheng et al. treated blood deficiency rats with Danggui and European Danggui and collected samples of their serum and urine.
T166 1933-2092 Sentence denotes The samples were later measured using 1H-CPMG-NMR, 1H-NOESYPRESAT-1D, 1H,1H-COSY, and 1H,13C-HSQC, and then compared to equivalent spectra from untreated rats.
T167 2093-2329 Sentence denotes The results showed that exposure to Danggui and European Danggui altered the levels of 18 different metabolites, such as lactate, nicotinamide, glycerol and formate, which were involved in a total of seven different metabolism pathways.
T168 2330-2503 Sentence denotes Additionally, it was proven that Danggui and European Danggui have different chemical compositions, with Danggui having better blood-enriching effects than European Danggui.