LitCovid-sentences  

PMC:7594251 / 129420-132613 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T907 0-40 Sentence denotes NMR Technique Advantages Disadvantages
T908 41-198 Sentence denotes 1D-NMR Ability to identify simple chemical compounds.High quality resolution and sensitivity for many 1D experiments.Less time consuming compared to 2D NMR.
T909 200-393 Sentence denotes Compared to 2D NMR less details can be obtained for more complex molecules.For nuclei other than 1H and 19F, relative sensitivity is fairly low—requires extra labeling to obtain better spectra.
T910 394-574 Sentence denotes 2D NMR Ability to identify complex molecules and observe different interactions between the nuclei, e.g., correlations between all spins in one spin system using TOCSY experiment.
T911 576-636 Sentence denotes Requires long times to obtain a proper spectra (up to days).
T912 637-697 Sentence denotes Ultrafast 2D NMR Greatly reduces time to obtain 2D spectra.
T913 699-719 Sentence denotes Reduced sensitivity.
T914 720-775 Sentence denotes SOFAST Significantly reduces acquisition time of HMQC.
T915 777-802 Sentence denotes Relatively low resolution
T916 803-882 Sentence denotes NUS Lowers the time of measurement while keeping the same level of resolution.
T917 884-985 Sentence denotes Requires use of reconstruction algorithms since missing data points can lead to artifacts in spectra.
T918 986-1116 Sentence denotes MDD Multidimensional data are “broken” to one dimensional, which are easier to analyze.Ability to resolve overlapping resonances.
T919 1119-1202 Sentence denotes Data must be (approximately) symmetrical (Lorentzian shape) to obtain good spectra.
T920 1203-1243 Sentence denotes CS Good reconstruction of weaker peaks.
T921 1245-1302 Sentence denotes Large computational costs, low performance on noisy data.
T922 1303-1354 Sentence denotes MAX ENT Significant reduction in acquisition time.
T923 1356-1443 Sentence denotes Nominally Lorentzian peak shapes may be distorted, and peak intensities may be altered.
T924 1444-1492 Sentence denotes IST Greatly reduced time to obtain NMR spectra.
T925 1494-1543 Sentence denotes Requires a grid of uniformly sampled data points.
T926 1544-1650 Sentence denotes FBDD Often makes stronger binding ligands from weakly binding fragments.Less time and resource intensive.
T927 1652-1713 Sentence denotes Can be used only for small fragments of compound of interest.
T928 1714-1766 Sentence denotes SAR Direct observation of target binding to ligand.
T929 1767-1813 Sentence denotes Several types of NMR experiments are possible.
T930 1815-1918 Sentence denotes Inability to distinguish binding modes, difficult to gage the “true” binding site of ligand to protein.
T931 1919-2028 Sentence denotes STD Only requires a small amount of sample.Highly reproducible.Allows direct observations of ligand binding.
T932 2030-2104 Sentence denotes Only works for ligands with low binding affinity (fast chemical exchange).
T933 2105-2144 Sentence denotes Inability to distinguish binding modes.
T934 2145-2221 Sentence denotes In cell NMR In vivo studies are possible, can focus on specific cell parts.
T935 2223-2267 Sentence denotes Special labeling techniques may be required.
T936 2268-2313 Sentence denotes Spectra may be more challenging to interpret.
T937 2314-2483 Sentence denotes In silico + NMR Can model protein drug interactions, helps speed up and reduce cost of drug delivery Protein models need to be validated through experimental approach.
T938 2484-2627 Sentence denotes PNMR Can observe proteins interacting with metal ions, long observation distance (10-25 angstroms) between paramagnetic left and nearby atoms.
T939 2629-2670 Sentence denotes Paramagnetic left required in the system.
T940 2671-2781 Sentence denotes ALARM NMR Elimination of false positives from HTS methods It requires synthesis of human La antigen protein.
T941 2782-2945 Sentence denotes ssNMR Enables the characterization of a chemical compound in a solid-state form such as a tablet/pill.Provides insight into the physical properties of a compound.
T942 2947-3034 Sentence denotes Significant broadening of the spectral lineshapes due to anisotropic spin interactions.
T943 3035-3123 Sentence denotes Relaxation editing Noticeable difference in spectra of binding and non-binding ligands.
T944 3125-3193 Sentence denotes Sets the lower limit of time for which experiments can be performed.