LitCovid-sentences  

PMC:7594251 / 129329-132613 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T906 0-90 Sentence denotes Table 3 Advantages and limitations of different NMR techniques developed in recent years.
T907 91-131 Sentence denotes NMR Technique Advantages Disadvantages
T908 132-289 Sentence denotes 1D-NMR Ability to identify simple chemical compounds.High quality resolution and sensitivity for many 1D experiments.Less time consuming compared to 2D NMR.
T909 291-484 Sentence denotes Compared to 2D NMR less details can be obtained for more complex molecules.For nuclei other than 1H and 19F, relative sensitivity is fairly low—requires extra labeling to obtain better spectra.
T910 485-665 Sentence denotes 2D NMR Ability to identify complex molecules and observe different interactions between the nuclei, e.g., correlations between all spins in one spin system using TOCSY experiment.
T911 667-727 Sentence denotes Requires long times to obtain a proper spectra (up to days).
T912 728-788 Sentence denotes Ultrafast 2D NMR Greatly reduces time to obtain 2D spectra.
T913 790-810 Sentence denotes Reduced sensitivity.
T914 811-866 Sentence denotes SOFAST Significantly reduces acquisition time of HMQC.
T915 868-893 Sentence denotes Relatively low resolution
T916 894-973 Sentence denotes NUS Lowers the time of measurement while keeping the same level of resolution.
T917 975-1076 Sentence denotes Requires use of reconstruction algorithms since missing data points can lead to artifacts in spectra.
T918 1077-1207 Sentence denotes MDD Multidimensional data are “broken” to one dimensional, which are easier to analyze.Ability to resolve overlapping resonances.
T919 1210-1293 Sentence denotes Data must be (approximately) symmetrical (Lorentzian shape) to obtain good spectra.
T920 1294-1334 Sentence denotes CS Good reconstruction of weaker peaks.
T921 1336-1393 Sentence denotes Large computational costs, low performance on noisy data.
T922 1394-1445 Sentence denotes MAX ENT Significant reduction in acquisition time.
T923 1447-1534 Sentence denotes Nominally Lorentzian peak shapes may be distorted, and peak intensities may be altered.
T924 1535-1583 Sentence denotes IST Greatly reduced time to obtain NMR spectra.
T925 1585-1634 Sentence denotes Requires a grid of uniformly sampled data points.
T926 1635-1741 Sentence denotes FBDD Often makes stronger binding ligands from weakly binding fragments.Less time and resource intensive.
T927 1743-1804 Sentence denotes Can be used only for small fragments of compound of interest.
T928 1805-1857 Sentence denotes SAR Direct observation of target binding to ligand.
T929 1858-1904 Sentence denotes Several types of NMR experiments are possible.
T930 1906-2009 Sentence denotes Inability to distinguish binding modes, difficult to gage the “true” binding site of ligand to protein.
T931 2010-2119 Sentence denotes STD Only requires a small amount of sample.Highly reproducible.Allows direct observations of ligand binding.
T932 2121-2195 Sentence denotes Only works for ligands with low binding affinity (fast chemical exchange).
T933 2196-2235 Sentence denotes Inability to distinguish binding modes.
T934 2236-2312 Sentence denotes In cell NMR In vivo studies are possible, can focus on specific cell parts.
T935 2314-2358 Sentence denotes Special labeling techniques may be required.
T936 2359-2404 Sentence denotes Spectra may be more challenging to interpret.
T937 2405-2574 Sentence denotes In silico + NMR Can model protein drug interactions, helps speed up and reduce cost of drug delivery Protein models need to be validated through experimental approach.
T938 2575-2718 Sentence denotes PNMR Can observe proteins interacting with metal ions, long observation distance (10-25 angstroms) between paramagnetic left and nearby atoms.
T939 2720-2761 Sentence denotes Paramagnetic left required in the system.
T940 2762-2872 Sentence denotes ALARM NMR Elimination of false positives from HTS methods It requires synthesis of human La antigen protein.
T941 2873-3036 Sentence denotes ssNMR Enables the characterization of a chemical compound in a solid-state form such as a tablet/pill.Provides insight into the physical properties of a compound.
T942 3038-3125 Sentence denotes Significant broadening of the spectral lineshapes due to anisotropic spin interactions.
T943 3126-3214 Sentence denotes Relaxation editing Noticeable difference in spectra of binding and non-binding ligands.
T944 3216-3284 Sentence denotes Sets the lower limit of time for which experiments can be performed.