LitCovid-sentences  

PMC:7589163 / 7199-10434 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T53 0-4 Sentence denotes 3.1.
T54 5-29 Sentence denotes Metabolism and Functions
T55 30-155 Sentence denotes Retinol (vitamin A1) is a fat-soluble vitamin and an obligatory dietary factor since it is not synthesized de novo by humans.
T56 156-346 Sentence denotes The main vitamin A sources are organ meats, milk, cheese; in green vegetables and yellow fruits are present provitamin A carotenoids, which must be cleaved to retinal before absorption [15].
T57 347-483 Sentence denotes Preformed vitamin A (retinol, retinal, retinoic acid, and retinyl ester) is hydrolysed into retinol in the lumen of the small intestine.
T58 484-628 Sentence denotes Retinol is esterified in the enterocyte and packaged into chylomicrons, and the liver represents the main site of chylomicron vitamin A storage.
T59 629-793 Sentence denotes During a deficiency status, vitamin A stores are mobilized, and retinol circulate bound to the retinol-binding protein (RBP) and is utilized by target tissues [15].
T60 794-1008 Sentence denotes The functions of vitamin A are mediated by all-trans-retinoic acid, which, by binding specific nuclear transcription factors, (retinoid receptors) regulates the expression of several hundred genes [15,16,17,18,19].
T61 1009-1204 Sentence denotes Vitamin A-regulated genes are involved in fundamental biological activities, playing an important role in supporting vision, growth, cell, and tissue differentiation, haematopoiesis and immunity.
T62 1205-1419 Sentence denotes Regarding immunity, vitamin A contributes to supporting the integrity of epithelia, particularly the gastrointestinal epithelia tissue among children suffering from severe infections or who are undernourished [15].
T63 1420-1553 Sentence denotes Vitamin A is also important in regulating the number and function of natural killer (NK) cells, macrophages, and neutrophils [16,17].
T64 1554-1749 Sentence denotes By downregulating the expression level of interferon (IFN)-γ and upregulating the secretion of inerleukin (IL)-5, vitamin A plays a regulatory role in the early differentiation stage of NK cells.
T65 1750-1919 Sentence denotes Moreover, it regulates the differentiation of dendritic cells precursors and promotes the secretion of the pro-inflammatory cytokines IL-12 and IL-23 by dendritic cells.
T66 1920-2091 Sentence denotes It has also a crucial role in promoting Foxp3+ Treg generation, while reciprocally inhibiting Th1/Th17 generation and a Th9 transcriptional and epigenomic program [20,21].
T67 2092-2238 Sentence denotes Furthermore, vitamin A is involved in the antimicrobial action of macrophages, playing a role in the phagocytic and oxidative burst activity [13].
T68 2239-2281 Sentence denotes Vitamin A also supports adaptive immunity.
T69 2282-2447 Sentence denotes Indeed, retinoids represents physiological modulators of normal B cell growth and differentiation, thus vitamin A deficiency negatively affects B cell function [18].
T70 2448-2556 Sentence denotes Furthermore, animal studies have shown impairment in the antibody response due to vitamin A deficiency [19].
T71 2557-2706 Sentence denotes The production of antibodies may be enhanced by the influence of vitamin A on T helper 2 cells development [22] and antigen-presenting cells [15,23].
T72 2707-2848 Sentence denotes In addition, retinoids induce the differentiation of Tregs and maintain both the stability of Tregs and their immunoregulatory function [24].
T73 2849-3067 Sentence denotes Indeed, retinoids play fundamental roles in cell-mediated immunity, representing an important cofactor in T cell activation [25] and influencing the expression of membrane receptors that mediate T-cell signalling [17].
T74 3068-3235 Sentence denotes Vitamin A supplementation trials conducted in paediatric populations have shown the potential effect to increase T-cell, particularly of the CD4 subpopulation [15,26].