| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T124 |
0-112 |
Sentence |
denotes |
Furthermore, vitamin C is effective in supporting both the humoral response and the cell-mediated immunity [46]. |
| T125 |
113-276 |
Sentence |
denotes |
Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of ROS, and ultimately microbial killing [57]. |
| T126 |
277-452 |
Sentence |
denotes |
It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage. |
| T127 |
453-633 |
Sentence |
denotes |
The role of vitamin C in lymphocytes is less clear, but it has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene-regulating effects. |
| T128 |
634-750 |
Sentence |
denotes |
The effect of vitamin C on cytokine generation appears to depend on the cell type and/or the inflammatory stimulant. |
| T129 |
751-887 |
Sentence |
denotes |
Recent research has indicated that vitamin C treatment attenuates synthesis of the pro-inflammatory cytokines TNF, IL-6, and IL-1β [57]. |
| T130 |
888-1157 |
Sentence |
denotes |
In vitro studies suggest that ascorbic acid operates as potent immunostimulator of antibody production (IgM and IgG) in humans and that the intracellular ascorbic acid content is a key parameter for establishing the immune response of peripheral blood lymphocytes [58]. |
| T131 |
1158-1250 |
Sentence |
denotes |
Other in vitro studies have shown the role of vitamin C in promoting T-cell maturation [59]. |
| T132 |
1251-1450 |
Sentence |
denotes |
Recent research indicates the possible role of vitamin C in regulating T-cell maturation via epigenetic mechanisms involving in the ten-eleven translocations (TETs) and histone demethylation [60,61]. |
