PMC:7571312 / 93671-94661 4 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T538 | 0-119 | Sentence | denotes | N2-(tert-Butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-5-methyl-l-norleucinamide |
| T539 | 120-410 | Sentence | denotes | Following the procedure described for the preparation of N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-l-leucinamide but substituting N-(tert-butoxycarbonyl)-5-methyl-l-norleucine and making noncritical variations provided a crude golden oil. |
| T540 | 411-573 | Sentence | denotes | This material was purified by Biotage flash chromatography, eluting with methanol/dichloromethane to afford the title compound as an off-white solid, 360 mg, 41%. |
| T541 | 574-990 | Sentence | denotes | 1H NMR (400 MHz, DMSO-d6) δ 8.45 (d, J = 8.1 Hz, 1H), 7.62 (s, 1H), 7.02 (d, J = 7.1 Hz, 1H), 4.49–4.62 (m, 2H), 4.33–4.44 (m, 1H), 3.78 (m, 1H), 3.15 (t, J = 8.7 Hz, 1H), 3.00–3.10 (m, 1H), 2.18–2.30 (m, 1H), 2.04–2.14 (m, 1H), 1.92–2.02 (m, 1H), 1.40–1.68 (m, 5H), 1.36 (s, 9H), 1.05–1.25 (m, J = 7.3 Hz, 2H), 0.83 (d, J = 1.52 Hz, 3H), 0.82 (d, J = 1.52 Hz, 3H); MS (API-ES+) for C20H34N3O5Cl m/z 454.2 (M + Na)+. |