PMC:7571312 / 63934-64933 4 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T399 | 0-273 | Sentence | denotes | Following the procedure described for the preparation of (3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-l-leucyl}amino)-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl acetate but substituting 2,6-dimethylbenzoic acid and making noncritical variations provided a crude brown foam. |
| T400 | 274-422 | Sentence | denotes | This material was purified by Biotage MPLC (25 M, 3–4% methanol/dichloromethane) to afford 177 mg (73%) of the title compound as an off-white glass. |
| T401 | 423-902 | Sentence | denotes | 1H NMR (DMSO-d6) δ 11.58 (d, J = 2 Hz, 1H), 8.63 (d, J = 8 Hz, 1H), 8.46 (d, J = 8 Hz, 1H), 7.65 (s, 1H), 7.36 (s, 1H), 7.25 (t, J = 8 Hz, 1H), 7.08 (m, 3H), 7.00 (d, J = 8 Hz, 1H), 6.49 (d, J = 8 Hz, 1H), 5.11 (s, 2H), 4.51 (m, 2H), 3.87 (s, 3H), 3.10 (m, 2H), 2.32–2.21 (m, 7H), 2.07 (m, 2H), 1.78–1.53 (m, 5H), 0.94 (d, J = 8 Hz, 3H), 0.89 (d, J = 8 Hz, 3H); MS (ESI+) for C33H40N4O7m/z 605.2 (M + H)+; anal. calcd for C33H40N4O7·0.3 H2O·0.2 CHCl3: C, 62.90; H, 6.49; N, 8.84. |
| T402 | 903-937 | Sentence | denotes | Found: C, 62.95; H, 6.42; N, 8.72. |
| T403 | 938-999 | Sentence | denotes | HRMS (ESI+) calcd for C33H40N4O7+H1 605.2970, found 605.2985. |