PMC:7571312 / 44565-45395 5 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T299 | 0-197 | Sentence | denotes | A solution of tert-butyl ((1S)-3-diazo-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl) carbamate (592 mg, 2.0 mmol) in 1,4-dioxane (7 mL) was placed under an atmosphere of N2 and cooled to 0 °C. |
| T300 | 198-359 | Sentence | denotes | This clear pale yellow solution was dropwise treated with a solution of 4 M hydrochloric acid in 1,4-dioxane (5 mL, 20 mmol) with copious gas evolution observed. |
| T301 | 360-465 | Sentence | denotes | Upon complete addition, the reaction was warmed to RT over 1 h with the formation of a white precipitate. |
| T302 | 466-603 | Sentence | denotes | The solid was collected by filtration, washed with diethyl ether, and dried to give 401 mg (83%) of the title compound as a white powder. |
| T303 | 604-830 | Sentence | denotes | 1H NMR (DMSO-d6) δ 8.76 (bs, 3H), 7.96 (s, 1H), 4.93 (d, J = 16 Hz, 1H), 4.80 (d, J = 16 Hz, 1H), 4.28 (m, 1H), 3.18 (m, 2H), 2.61 (m, 1H), 2.30 (m, 1H), 1.93 (m, 2H), 1.70 (m, 1H); MS (ESI+) for C8H13ClN2O2m/z 205.0 (M + H)+. |