LitCovid-sentences  

PMC:7571312 / 35060-37077 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T239 0-112 Sentence denotes Unless otherwise noted, materials were obtained from commercial suppliers and used without further purification.
T240 113-266 Sentence denotes The removal of solvent under reduced pressure or concentration refers to distillation using a Büchi rotary evaporator attached to a vacuum pump (3 mmHg).
T241 267-349 Sentence denotes Products obtained as solids or high-boiling oils were dried under vacuum (1 mmHg).
T242 350-476 Sentence denotes Silica gel chromatography was performed on either a CombiFlash (Teledyne ISCO), SP4, or Isolera (Biotage) purification system.
T243 477-677 Sentence denotes All reactions were performed under a positive pressure of nitrogen or argon or with a drying tube at an ambient temperature (unless otherwise stated) in anhydrous solvents, unless otherwise indicated.
T244 678-847 Sentence denotes Analytical thin-layer chromatography (TLC) was performed on glass-backed silica gel 60 F254 plates (Analtech, 0.25 mm), eluting with the appropriate solvent ratio (v/v).
T245 848-1018 Sentence denotes The reactions were assayed by high-performance liquid chromatography–mass spectrometry (LCMS) or TLC and terminated as judged by the consumption of the starting material.
T246 1019-1189 Sentence denotes LCMS utilized wavelengths of 254 and 220 nm and either electrospray ionization (ESI) in positive mode or atmospheric-pressure chemical ionization (APCI) in positive mode.
T247 1190-1294 Sentence denotes The TLC plates were visualized using UV light, p-anisaldehyde, phosphomolybdic acid, or iodine staining.
T248 1295-1356 Sentence denotes Microwave-assisted reactions were run in a Biotage Initiator.
T249 1357-1430 Sentence denotes 1H NMR spectra were recorded on a Bruker XWIN-NMR (400 MHz) spectrometer.
T250 1431-1527 Sentence denotes Proton chemical shifts are reported in parts per million downfield from tetramethylsilane (TMS).
T251 1528-1618 Sentence denotes 1H NMR data are reported as chemical shift (multiplicity, coupling constant, integration).
T252 1619-1779 Sentence denotes Multiplicities are denoted as follows: s, singlet; d, doublet; t, triplet; q, quartet; dd, doublet of doublets; dt, doublet of triplets; and brs, broad singlet.
T253 1780-1930 Sentence denotes For spectra obtained in CDCl3, DMSO-d6, and CD3OD, the residual protons (7.27, 2.50, and 3.31 ppm, respectively) were used as the internal references.
T254 1931-2017 Sentence denotes The purity of the final products is >95% as determined by HPLC and/or 1H NMR analyses.