Id |
Subject |
Object |
Predicate |
Lexical cue |
T232 |
0-11 |
Sentence |
denotes |
Conclusions |
T233 |
12-215 |
Sentence |
denotes |
This report details the efforts to identify irreversible and reversible peptidomimetic inhibitors of the SARS CoV-1 3CLpro as potential IV agents for the treatment of SARS and other coronavirus diseases. |
T234 |
216-332 |
Sentence |
denotes |
Two classes, acyloxymethylketones and hydroxymethylketones, were discovered as potent inhibitors of the SARS 3CLpro. |
T235 |
333-443 |
Sentence |
denotes |
The hydroxymethylketone derivative 4 demonstrated potent SARS CoV-1 inhibition in 3CLpro and antiviral assays. |
T236 |
444-790 |
Sentence |
denotes |
Additionally, 4 possesses acceptable solubility, stability in plasma, and low in vitro and in vivo clearances suitable for further development as a coronavirus treatment.49 Importantly, the potent inhibition of SARS CoV-2 3CLpro has prompted further preclinical investigations of 4 as a potential therapeutic treatment for patients with COVID-19. |