PMC:7571312 / 101828-102681 4 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T569 | 0-111 | Sentence | denotes | N-(tert-Butoxycarbonyl)-N-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-l-phenylalaninamide |
| T570 | 112-366 | Sentence | denotes | Following the procedure described for the preparation of N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-l-leucinamide but substituting Boc-Phe-OH and making noncritical variations provided a crude brown oil. |
| T571 | 367-524 | Sentence | denotes | This material was purified by Biotage flash chromatography, eluting with methanol/dichloromethane to afford the title compound as a white solid, 351 mg, 36%. |
| T572 | 525-853 | Sentence | denotes | 1H NMR (400 MHz, CDCl3) δ 8.02 (s, 1H), 7.19–7.31 (m, 5H), 5.77 (s, 1H), 5.10 (d, J = 6.1 Hz, 1H), 4.52–4.57 (m, 1H), 4.44 (m, 1H), 4.01–4.12 (m, 2H), 3.26–3.37 (m, 2H), 3.01–3.08 (m, 2H), 2.29–2.37 (m, 1H), 2.15–2.25 (m, 1H), 1.98–2.06 (m, 1H), 1.75–1.91 (m, 2H), 1.40 (s, 9H); MS (API-ES−) for C22H30N3O5Cl m/z 450.2 (M – H)−. |