| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T362 |
0-163 |
Sentence |
denotes |
Further studies into the therapeutic potential of other autophagy inducers for exacerbations in chronic respiratory diseases have shown promise as well (Figure 2). |
| T363 |
164-339 |
Sentence |
denotes |
These studies have demonstrated that rapamycin can induce autophagy and aid in the killing of different types of bacteria that are known to cause exacerbations [6,44,153,202]. |
| T364 |
340-529 |
Sentence |
denotes |
Similarly, fisetin, which is an over the counter antioxidant used for brain health, induces autophagy [34,43] to improve bacterial clearance by ameliorating CFTR-autophagy dysfunction [35]. |
| T365 |
530-651 |
Sentence |
denotes |
Thus, the use of various autophagy inducers shows promise in restoring the CFTR-autophagy pathway to treat exacerbations. |
| T366 |
652-868 |
Sentence |
denotes |
However, future studies and clinical trials need to be conducted to evaluate and standardize the safety and efficacy of these treatments to provide benefit in human subjects as a part of ongoing clinical development. |
