| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T151 |
0-173 |
Sentence |
denotes |
As recent studies have found, severe COVID-19 is commonly complicated with coagulopathy, including disseminated intravascular coagulation and venous thromboembolism [33,34]. |
| T152 |
174-348 |
Sentence |
denotes |
For this reason, the administration of heparin has been recommended for COVID-19 patients according to expert consensus [4,31], although its efficacy remains to be validated. |
| T153 |
349-634 |
Sentence |
denotes |
In a study of 449 patients with severe COVID-19 and sepsis-induced coagulopathy criteria or with markedly elevated D-dimer levels (higher than sixfold of upper limit of normal), anticoagulant therapy, mainly with low-molecular-weight heparin, was associated with better prognosis [34]. |
| T154 |
635-767 |
Sentence |
denotes |
Beyond severe coagulopathy, special attention to venous thromboembolism prophylaxis is necessary in the management of COVID-19 [35]. |
| T155 |
768-946 |
Sentence |
denotes |
Low-molecular-weight heparin is preferred over unfractionated heparin in order to reduce patient contact (depending on the patient’s bleeding risk and creatinine clearance) [36]. |
| T156 |
947-1072 |
Sentence |
denotes |
We found that all protocols analyzed included anticoagulant treatment, with low-molecular-weight heparin as the first option. |
| T157 |
1073-1161 |
Sentence |
denotes |
It was recommended that all hospitalized COVID-19 patients receive prophylactic heparin. |
| T158 |
1162-1288 |
Sentence |
denotes |
This recommendation was extended to after discharge if necessitated by the patient’s clinical condition in 46.6% of protocols. |
| T159 |
1289-1413 |
Sentence |
denotes |
An increase in prophylactic heparin doses was recommended in 53.3% of the protocols for patients at high risk of thrombosis. |
| T160 |
1414-1571 |
Sentence |
denotes |
In five protocols (33.3%), heparin was increased to therapeutic doses if the condition was critical or if there was a progressive increase in D-dimer levels. |
| T161 |
1572-1662 |
Sentence |
denotes |
All protocol included therapeutic heparin if there was evidence of venous thromboembolism. |
