PMC:7558914 / 19603-20752 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T127 0-142 Sentence denotes Lopinavir/ritonavir has had the same limitations of use as hydroxychloroquine/chloroquine, with no clear benefits beyond standard care [3,23].
T128 143-406 Sentence denotes Considering the uncertainty and the likely increase in gastrointestinal side effects, principal guidelines around the world have not contemplated its use in patients with COVID-19 [4,18,19,20] or have only considered it in the context of a clinical trial [21,22].
T129 407-486 Sentence denotes Remdesivir was only considered when patients were enrolled in a clinical trial.
T130 487-703 Sentence denotes Randomized controlled trials have reported that remdesivir reduces the duration of mechanical ventilation and time to symptom resolution, but its effect on mortality and other adverse outcomes remains uncertain [24].
T131 704-766 Sentence denotes Other antivirals were not routinely included in our protocols.
T132 767-978 Sentence denotes Antiviral agents such as oseltamivir, umifenovir, favipiravir, or ribavirin as well as miscellaneous agents such as interferon-α or interferon-β are being studied for use as possible treatments for COVID-19 [3].
T133 979-1149 Sentence denotes Currently, principal guidelines have either not reported any recommendation for their use [4,18,19,20,21] or have suggested not using them in patients with COVID-19 [22].