LitCovid-sentences  

PMC:7558333 / 12076-14677 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T96 0-4 Sentence denotes 3.4.
T97 5-74 Sentence denotes Relevance of Various Tests and Categorization of Patients and Outcome
T98 75-175 Sentence denotes Table 6 presents the classification of the 45 patients using original or modified AspICU algorithms.
T99 176-293 Sentence denotes It appears that using an AspICU algorithm, nine patients were considered as having a putative IA (22% of the cohort).
T100 294-527 Sentence denotes When including PCR, the number of patients with putative IA would increase from 9 to 15 (33%) patients, while most patients might be only colonized because all presented compatible clinical signs and abnormal chest CT scan (Table 5).
T101 528-694 Sentence denotes Regarding Aspergillus detection, eight patients had a single detection of fungi using culture and/or PCR in respiratory samples and thus were classified as colonized.
T102 695-857 Sentence denotes One of these patients had a concomitant GM detection in serum (index = 0.551), was not treated and is still alive, thus was considered as a false positive result.
T103 858-996 Sentence denotes Finally, seven (16%) patients presented a heavy burden of Aspergillus in the respiratory tract with repeated positive cultures and/or PCR.
T104 997-1140 Sentence denotes In order to rule out a chronic colonization before the episode, an anti-Aspergillus antibody testing was performed and showed negative results.
T105 1141-1360 Sentence denotes These patients were classified as putative IA, and three of them could even be considered as probable IA because of a positive biomarker of angioinvasion (serum PCR and/or GM) in agreement with EORTC/MSG classification.
T106 1361-1485 Sentence denotes Interestingly, following these classification criteria, CT scan abnormalities showed a gradation according to patient group.
T107 1486-1751 Sentence denotes Diffuse reticular or alveolar opacities were observed in patients classified as probable IA (Figure 2), nodules in half of putative IA, and in colonized patients, only non-specific and hard to interpret signs in the context of COVID-19 infection could be described.
T108 1752-2019 Sentence denotes In addition, putative/probable aspergillosis patients appeared more severely ill than patients without aspergillosis, since SOFA score at day seven was significantly higher in this group (p = 0.01) with a continuum between no infection, colonization and IA (Table 5).
T109 2020-2231 Sentence denotes Similarly, the mean ICU length of stay increased significantly from 12 days in patients without aspergillosis to 23 days in colonized patients, and 27 days in putative/probable invasive aspergillosis (p = 0.02).
T110 2232-2328 Sentence denotes All patients with a putative/probable IA were treated either with voriconazole or isavuconazole.
T111 2329-2386 Sentence denotes Only one colonized patient was treated with voriconazole.
T112 2387-2601 Sentence denotes Six patients died; there was a trend towards higher mortality in the group of putative/probable IA compared to uninfected patients, although not significant (2/7; 28.6%) versus 4/30 (13.3%), respectively (Table 7).