LitCovid-sentences  

PMC:7556165 / 72724-76636 JSONTXT 17 Projects

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Id Subject Object Predicate Lexical cue
T428 0-23 Sentence denotes ACE2 and Other Diseases
T429 24-78 Sentence denotes ACE2 is a multiform protein (Feng et al., 2010, 2011).
T430 79-269 Sentence denotes As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013).
T431 270-382 Sentence denotes Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis.
T432 383-500 Sentence denotes Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012).
T433 501-598 Sentence denotes Moreover, ACE2 participates in the regulation of metabolism, particularly of glucose homeostasis.
T434 599-706 Sentence denotes In the pancreas, activation of the ACE2-Ang1-7-MasR pathway improves insulin secretion (Yuan et al., 2013).
T435 707-893 Sentence denotes Obesity and high-fat diets cause a reduction in ACE2 expression in the adipose tissue, which in turn results in increased blood pressure (Gupte et al., 2008, 2012; Carsana et al., 2020).
T436 894-1039 Sentence denotes A role for ACE2 is emerging in Alzheimer disease, since it has been shown that ACE2 can hydrolyse Beta amyloid peptides (Zou et al., 2007, 2013).
T437 1040-1123 Sentence denotes There is also increasing evidence that the RAAS system may be implicated in cancer.
T438 1124-1324 Sentence denotes ACE2 was found to inhibit cancer cell growth, metastasis, and angiogenesis in breast (Yu et al., 2016; Zhang Q. et al., 2019), pancreatic (Zhou et al., 2011), and colon cancer (Bernardi et al., 2012).
T439 1325-1534 Sentence denotes Another study pointed out that hepatocellular carcinoma patients with higher levels of ACE2 had longer survival times, suggesting a positive link between ACE2 expression and better prognosis (Ye et al., 2015).
T440 1535-1701 Sentence denotes Studies on human xenografts in mice clearly indicated that ACE2 inhibited tumor growth by suppressing invasion and angiogenesis in Non-Small Cell Lung Cancer (NSCLC).
T441 1702-1975 Sentence denotes Remarkably, the same group demonstrated that overexpression of ACE2 promotes the expression of E-cadherin at expenses of mesenchymal markers such as vimentin, and thereby inhibits the epithelial-mesenchymal transition in NSCLC models (Feng et al., 2010; Qian et al., 2013).
T442 1976-2182 Sentence denotes The discovery that lung cancer patients that harbor COVID-19 display more severe symptoms (Liang et al., 2020) set out intensive research on the possible connection between malignancies and ACE2 expression.
T443 2183-2300 Sentence denotes A thorough bioinformatics analysis of the TCGA dataset on several kinds of cancer (Chai et al., 2020) has shown that:
T444 2301-2369 Sentence denotes (1) Mutation and amplification of ACE2 gene are frequent in cancer.
T445 2370-2475 Sentence denotes Yet, hot-spot mutation sites were never observed, as ACE2 mutations were distributed across all 18 exons.
T446 2476-2732 Sentence denotes (2) ACE2 transcription was upregulated in six tumors: colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and lung adenocarcinoma (LUAD).
T447 2733-2820 Sentence denotes Interestingly, ACE2 transcription was unchanged in lung squamous cell carcinoma (LUSC).
T448 2821-2965 Sentence denotes (3) ACE2 transcription was downregulated in three tumors: testicular germ cell (TGCT), thyroid carcinoma (THCA), and kidney chromophobe (KICH).
T449 2966-3121 Sentence denotes (4) Changes of ACE2 transcription were epigenetic in nature, as both mutation and copy variation of ACE2 did not correlate with its up- or downregulation.
T450 3122-3226 Sentence denotes (5) In most cases, changes of ACE2 transcription strongly correlated with methylation in ACE2 promoter.
T451 3227-3357 Sentence denotes More specifically, decreased methylation levels correlated with upregulation, whereas increased methylation led to downregulation.
T452 3358-3445 Sentence denotes (6) No prognostic role of ACE2 expression on patient’s survival could be demonstrated.
T453 3446-3566 Sentence denotes These data confirm the remarkable role of methylation in determining the ACE2 expression, as described in paragraph 2.2.
T454 3567-3912 Sentence denotes Interestingly, a second bioinformatics study on Oncomine and TCGA databases gave slightly different results in terms of tumor-associated ACE2 expression changes, but confirmed the role of promoter hypomethylation in KIRP and uterine corpus endometrial carcinoma (UCEC) where ACE2 transcription was significantly upregulated (Yang et al., 2020a).