LitCovid-sentences  

PMC:7556165 / 6064-7721 JSONTXT 17 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T41 0-188 Sentence denotes Following the ACE discovery in mid-1950s, despite intense research in the field, no human homologs of the enzyme have been found for more than 50 years (Isaac et al., 1998; Riordan, 2003).
T42 189-340 Sentence denotes It was only in 2000 that two independent research groups identified, almost simultaneously, a new human ACE-like enzyme, with two different approaches.
T43 341-520 Sentence denotes Tipnis et al. (2000) searched for new metalloproteases in an expressed sequence tag (EST) database, finding an ACE homolog (ACEH) with a single domain, similar to that of insects.
T44 521-584 Sentence denotes Subsequently they cloned it from a human lymphoma cDNA library.
T45 585-773 Sentence denotes Interestingly ACEH showed high homology (40% identity and 60% similarity) with ACE, particularly around the HEXXH sequence and highly conserved glutamate residue, involved in zinc binding.
T46 774-866 Sentence denotes Moreover, they demonstrated the presence of seven glycosylation sites (Tipnis et al., 2000).
T47 867-1187 Sentence denotes In the same year, Donoghue et al. (2000b) were searching for new genes involved in heart failure and identified a human cDNA ACE homolog, named ACE2, among 19,000 5’end sequences by RACE (rapid amplification of cDNA ends) in the heart ventricle cDNA library, obtained from a woman with idiopathic dilated cardiomyopathy.
T48 1188-1290 Sentence denotes ACE2 showed a transmembrane domain, a zinc catalytic domain 42% identical to ACE and a signal peptide.
T49 1291-1348 Sentence denotes Like ACE, ACE2 seemed to be an ectoenzyme type I protein.
T50 1349-1517 Sentence denotes The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b).
T51 1518-1657 Sentence denotes In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.