LitCovid-sentences  

PMC:7556165 / 4655-7721 JSONTXT 17 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T33 0-29 Sentence denotes ACE System and ACE2 Discovery
T34 30-253 Sentence denotes Human Angiotensin-converting enzyme (ACE) belongs to the M2 gluzincin family of metalloproteinases and (Ehlers and Riordan, 1989; Masuyer et al., 2014) exists in two forms, namely somatic ACE (sACE) and germinal ACE (tACE).
T35 254-476 Sentence denotes Both are derived from the same gene, controlled by alternative promotors. sACE is an integral membrane protein, which can be also cleaved by ACE secretases to produce a circulating form of the enzyme (Natesh et al., 2003).
T36 477-713 Sentence denotes sACE, hereafter referred to simply as ACE, has been extensively studied, because of its crucial role in the homeostasis of renin-angiotensin-aldosterone (RAAS) system and in cardiovascular diseases (Takimoto-Ohnishi and Murakami, 2019).
T37 714-947 Sentence denotes The two extracellular domains N and C domains of ACE (Wei et al., 1991; Jaspard et al., 1993; Natesh et al., 2003; Riordan, 2003) can both hydrolase two crucial peptides, namely angiotensin I and bradykinin, with the same efficiency.
T38 948-1168 Sentence denotes Indeed, ACE carries out the cleavage of two amino acids (dipeptidase action) from the C-terminal part of angiotensin I to generate angiotensin II, which exerts a potent vasopressor, proliferative, and profibrotic effect.
T39 1169-1280 Sentence denotes Moreover, ACE mediates the cleavage and inactivation of bradykinin, which is a vasodilator hypotensive peptide.
T40 1281-1408 Sentence denotes The pivotal role of ACE in the RAAS system allows a refined blood pressure control and salt homeostasis (Sayer and Bhat, 2014).
T41 1409-1597 Sentence denotes Following the ACE discovery in mid-1950s, despite intense research in the field, no human homologs of the enzyme have been found for more than 50 years (Isaac et al., 1998; Riordan, 2003).
T42 1598-1749 Sentence denotes It was only in 2000 that two independent research groups identified, almost simultaneously, a new human ACE-like enzyme, with two different approaches.
T43 1750-1929 Sentence denotes Tipnis et al. (2000) searched for new metalloproteases in an expressed sequence tag (EST) database, finding an ACE homolog (ACEH) with a single domain, similar to that of insects.
T44 1930-1993 Sentence denotes Subsequently they cloned it from a human lymphoma cDNA library.
T45 1994-2182 Sentence denotes Interestingly ACEH showed high homology (40% identity and 60% similarity) with ACE, particularly around the HEXXH sequence and highly conserved glutamate residue, involved in zinc binding.
T46 2183-2275 Sentence denotes Moreover, they demonstrated the presence of seven glycosylation sites (Tipnis et al., 2000).
T47 2276-2596 Sentence denotes In the same year, Donoghue et al. (2000b) were searching for new genes involved in heart failure and identified a human cDNA ACE homolog, named ACE2, among 19,000 5’end sequences by RACE (rapid amplification of cDNA ends) in the heart ventricle cDNA library, obtained from a woman with idiopathic dilated cardiomyopathy.
T48 2597-2699 Sentence denotes ACE2 showed a transmembrane domain, a zinc catalytic domain 42% identical to ACE and a signal peptide.
T49 2700-2757 Sentence denotes Like ACE, ACE2 seemed to be an ectoenzyme type I protein.
T50 2758-2926 Sentence denotes The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b).
T51 2927-3066 Sentence denotes In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.