| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T270 |
0-85 |
Sentence |
denotes |
FIGURE 7 Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells. |
| T271 |
86-246 |
Sentence |
denotes |
The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell. |
| T272 |
247-472 |
Sentence |
denotes |
The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA. |
| T273 |
473-783 |
Sentence |
denotes |
Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles. |
| T274 |
784-894 |
Sentence |
denotes |
Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell. |
