| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T252 |
40-103 |
Sentence |
denotes |
Initially, the S protein is in the pre-fusion native state (1). |
| T253 |
104-402 |
Sentence |
denotes |
Then S undergoes priming of the S1 subunit at S1/S2 by local proteases yielding the pre-fusion metastable state (2); note that priming at S1/S2 could also happen upon virus formation in releasing cell: in such a case the virus attaches to a host cell already in the pre-fusion metastable state (2). |
| T254 |
403-582 |
Sentence |
denotes |
Subsequent triggering by a protease on S2’ enables the FP to insert in the host membrane upon the “jack-knife” transition of HR1 and HR2 yielding the pre-hairpin intermediate (3). |
| T255 |
583-697 |
Sentence |
denotes |
The pre-hairpin folds back on itself due to HR1 and HR2 interactions eventually forming the post-fusion (6) state. |
| T256 |
698-868 |
Sentence |
denotes |
During the S protein foldback, the two membranes approach each other until the outer leaflets merge (hemifusion) and eventually the inner leaflets merge (pore formation). |
| T257 |
869-990 |
Sentence |
denotes |
Note that cell membrane may refer to plasma membrane (direct fusion) or endosomal membrane (fusion in endocytic vesicle). |
| T258 |
991-1023 |
Sentence |
denotes |
Adapted from Tang et al. (2020). |
