| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T23 |
0-71 |
Sentence |
denotes |
In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered. |
| T24 |
72-171 |
Sentence |
denotes |
It showed a different substrate selectively, and in particular it could not activate angiotensin I. |
| T25 |
172-238 |
Sentence |
denotes |
At the same time, it was not a target of classical ACE inhibitors. |
| T26 |
239-438 |
Sentence |
denotes |
Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced. |
| T27 |
439-611 |
Sentence |
denotes |
In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2. |
| T28 |
612-826 |
Sentence |
denotes |
Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types. |
