| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T186 |
0-107 |
Sentence |
denotes |
Other substrates of ACE2 include apelin-13/17, neurotensin, dynorphin A (1–13), and ghrelin (Turner, 2015). |
| T187 |
108-310 |
Sentence |
denotes |
Interestingly peptides of apelin family have been demonstrated to upregulate ACE2 expression in physiological condition and more actively during heart failure in in vivo experiments (Sato et al., 2013). |
| T188 |
311-575 |
Sentence |
denotes |
ACE2 in turn is able to regulate apelin bioavailability, establishing a negative feedback loop, and the crosstalk between RAAS, ACE2 and Apelin system might play a significant role in the pathophysiology of hypertension (Kalea and Batlle, 2010; Chen et al., 2015). |
